IRCT20221001056068N1 IRCT 2022-11-22 Esfahan University of Medical Sciences Comparing the effects of ovarian stimulation in infertile patients Comparison of ovarian stimulation in proliferative and luteal phases in an ovarian cycle (DuoStim method) in patients with poor ovarian response 2022-10-02 anticipated 26 Complete https://irct.ir/trial/66187 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A infertility. Intervention group: In the DuoStim method, ovarian stimulation is performed in both ovarian phases. From the third day of menstruation, all poor ovarian response patients who are candidates for in vitro fertilization undergo ovulation stimulation with gonadotropin at a dose of 300 units daily with Karma brand human gonadotropin (HMG) 150 units and Sinnal brand recombinant follicle stimulation hormone (FSH) 150 units. When the follicle diameter is higher than 14 mm, gonadotropin releasing hormone (GnRH) antagonist with Steronax brand 0.25 is used daily, and when at least two follicles with a diameter of 17 mm are seen through vaginal ultrasound with volusonE6 brand ultrasound machine, Ovitrol is used to trigger the oocyte of the patients. 250 single doses are used. Before transferring to the operating room for ovulation, polymerase chain reaction (PCR) test for COVID19 is requested from the couple, and if the corona test is negative, ovulation is performed. (Proliferative phase) On the same day, a sperm sample is taken from the wife and prepared by a laboratory process and microinjection is performed by an embryologist. Then, 3 days after ovulation, vaginal ultrasound is performed again to see the follicle, and the same drugs as mentioned (HMG and recombinant FSH and then GnRH antagonist) are started and continue with Ovitrol until the trigger time. Then ovulation is done (luteal phase) and on the same day, a sperm sample is taken from the wife and prepared by a laboratory process and microinjection is done by an embryologist.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Compliance with ethical standards and the right to preserve the information of the research center