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IRCT20220921056008N1 IRCT 2022-10-19 Islamic Azad University Effect of myo-inositol on PCOS Effect of myo-inositol on the expression of survivin and caspase 3&7 genes in granulosa cells and the level of biochemical factors of follicular fluid and its relation on oocytes and embryos quality in patients with PCOs undergoing ICSI treatment 2022-05-22 anticipated 60 Complete https://irct.ir/trial/66005 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Other, Purpose: Treatment, Randomization description: In order to avoid biased answers, PCOS patients were divided into two groups with equal numbers by a simple random method in such a way that 60 beads are placed in a box numbered from 1 to 60 and from each number There are 1 beads in the box. After accepting each patient and after obtaining informed consent, the treating doctor randomly removes one of the beads inside the box (without seeing the contents of the box) and in this way the people are classified into different groups, so that Odd numbers belong to the first intervention group (Inositol) and even numbers belong to the second intervention group (Acidfolic), Blinding description: The type of research is double-blind and only the researcher knows how to group the patients. The type of drug regimen is presented to the patient by the doctor, but both the doctor and the patient are not in the process of dividing the research intervention groups, and only the researcher is in the process of dividing the patients in It is groups. The method of blinding will be in such a way that the patient is unaware of the type of treatment he will receive and the control group will receive a placebo. After dividing the participants into experimental groups and the control group, the method of performing the exercises and the exact duration of the exercises will be explained to the volunteers to participate in the research. They declare themselves to participate in the research. The conditions for entering the exam include having at least one year of infertility due to female causes (polycystic ovary syndrome) and being in good health in terms of other diseases. 2-3 Polycystic ovary syndrome. Intervention 1: Intervention group:This group includes 30 patients with polycystic ovary syndrome who were candidates for infertility treatment with ICSI according to the opinion of the gynecologist. These patients received 2000 mg of inositol daily during the ICSI (implantation) cycle for three weeks (FairhavenHealth- (IRAN company) along with 1 mg of folic acid (Raha-Iran company). Then, after ovarian puncture, follicular fluid and granulosa cells and eggs are checked in terms of chemical and chemical parameters. Intervention 2: Control group: This group includes 30 patients with polycystic ovary syndrome who are candidates for infertility treatment with ICSI according to the opinion of the gynecologist. During the ICSI (embryo implantation) cycle, these patients receive one milligram of folic acid daily (Reha company) for three weeks. -Iran) are consumed, then after ovarian puncture, follicular fluid and granulosa cells and other biochemical and hormonal parameters as well as the quality of eggs are checked. Yes - There is a plan to make this available What will be shared: All information related to potential data can be shared after de-identifying individuals When: The access period starts 6 months after the results are published To whom: Researchers working in universities and scientific institutions Conditions: Provide a relevant university degree Where to obtain: z_yazdanpanah68@yahoo.com How to obtain: After receiving the request via email, the data will be sent within a week Comments:
public Zeynab Yazdanpanah
Zomorrod building. Alley 52. 19th Street
Qom Iran (Islamic Republic of) ۳۷۱۳۶۵۹۴۳۷ +98 25 3760 8379 zyazdanpanah@piau.ac.ir Islamic Azad University scientific Mitra Heydari Nasrabadi
Islamic Azad University, Parand branch. Bahonar Blvd.Parand city.Kilometer 32 of Tehran Saveh highway
Parand Iran (Islamic Republic of) ۳۷۶۱۳۹۶۳۶۱ +98 21 5673 3001 heydarimitra45@gmail.com Islamic Azad University Iran (Islamic Republic of) PCOS diagnostic criteria based on the Rotterdam consensus 20 years 40 years Female Male factor infertility. Cushing syndrome. Congenital adrenal hyperplasia. Thyroid dysfunction, hyperprolactinemia, androgen secretion neoplasia, diabetes mellitus Treatment - Drugs Treatment - Drugs Intervention group:This group includes 30 patients with polycystic ovary syndrome who were candidates for infertility treatment with ICSI according to the opinion of the gynecologist. These patients received 2000 mg of inositol daily during the ICSI (implantation) cycle for three weeks (FairhavenHealth- (IRAN company) along with 1 mg of folic acid (Raha-Iran company). Then, after ovarian puncture, follicular fluid and granulosa cells and eggs are checked in terms of chemical and chemical parameters Control group: This group includes 30 patients with polycystic ovary syndrome who are candidates for infertility treatment with ICSI according to the opinion of the gynecologist. During the ICSI (embryo implantation) cycle, these patients receive one milligram of folic acid daily (Reha company) for three weeks. -Iran) are consumed, then after ovarian puncture, follicular fluid and granulosa cells and other biochemical and hormonal parameters as well as the quality of eggs are checked The level of gene expression of caspase 3 and 7 and survivin. Timepoint: After ovarian puncture. Method of measurement: Real time PCR. Islamic Azad University Approved 2021-08-31 Ethics Committee of Islamic Azad University, Varamin-Pishva branch Islamic Azad University, Parand branch.Parand city - Bahonar boulevard .Kilometer 32 of Tehran Saveh highway. Parand Tehran Iran (Islamic Republic of)