IRCT20190624043991N19 IRCT 2022-10-15 Tehran University of Medical Sciences The effect of probiotics on the prevention of bacterial biofilm formation on double J Evaluation of the effect of probiotics on the prevention of bacterial biofilm formation on double J implanted in patients due to urological problems 2022-11-01 anticipated 108 Complete https://irct.ir/trial/65967 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: -, Randomization description: The present study is a double-blind randomized clinical trial. For randomization, the blanced block randomization method is used to generate quadruple blocks.According to the randomization method, we expect the two groups to differ by a maximum of 2 people in terms of the number of people assigned. After the methodologist prepares the randomization sequence using the sealdenvelop online site, the generated sequence will be made available to a technician outside the research team. Quadruple blocks (A or B) are placed in envelopes.After the arrival of the first patient with the inclusion criteria, the envelopes are randomly selected and the type of patient group is informed to the research team through a trained technician. Based on the randomly selected envelope, the patient is placed in the (A) double J plus placebo or (B) double J plus probiotic treatment group, Blinding description: Patients who have agreed to participate in the study and the therapist for the blinding process, envelopes related to the type of intervention are provided only to the technician. The researcher (to avoid bias) and the patient are not informed of the type of intervention (double J plus placebo or double J plus probiotic). Placebo, a capsule containing sugar, which looks similar to a probiotic capsule, is prescribed for 4 weeks. 3 Urinary tract infection. Intervention 1: Intervention group: Intervention group: Patients receiving double J with placebo.Placebo capsule containing sugar, which is similar to probiotic capsule in terms of appearance and quantity, and is prescribed once a day for 4 weeks. Intervention 2: Intervention group: Patients receiving double J with probiotic capsules. Probiotic capsules are prescribed once a day for 4 weeks. Yes - There is a plan to make this available What will be shared: Demographic information anonymously When: One year after publication To whom: Researchers working in academia, physicians, surgeons and hospitals Conditions: Any analysis can be done with the consent of the main researcher Where to obtain: Sina Hospital, Urology Research Center, Head of Urology Research Center: Dr. Seyed Mohammad Kazem Aghamir 00982166348560 How to obtain: After reviewing the information by the administrator and epidemiologist, the patient information will be available for the applicant by the provision of a patient's privacy. Comments: -