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IRCT20220909055923N1 IRCT 2022-09-10 Tabriz University of Medical Sciences The effect of Ibuprofen and Meloxicam on dental anesthesia Comparison of Premedication Using Ibuprofen and Meloxicam on the success rate of Inferior Alveolar Nerve Block in mandibular first molars with symptomatic Irreversible Pulpitis 2022-09-10 anticipated 165 Complete https://irct.ir/trial/65808 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Random sampling will be done among the patients referred to the endodontics department of Tabriz Faculty of Dentistry who are eligible for the study. The randomization method is simple and its unit is individual. Our tool for randomizing a table of random numbers. Based on this, the type of treatment is marked with code A (Ibuprofen), B (Meloxicam), and code C (placebo/powdered lactose) and placed inside sealed envelopes. Then the envelopes are placed in a bag and mixed. Then it is randomly selected from the bag and treatment is given to the patient by observing the code. None of the patients will be informed about the treatment of another patient, Blinding description: This study is double-blind, and the patients do not know about the type of group they will be included in. A researcher will not know about the type of medicine. Patients are aware of the existence of several types of treatment, but they do not know which group they belong to. N/A Dental caries. Intervention 1: Intervention group 1: Ibuprofen capsule 800 mg (Reha Pharmaceuticals) will be used one hour before root canal treatment. Before starting the treatment, their pain level is recorded. One hour after the oral administration of the capsule, all patients are under lidocaine and epinephrine anesthesia. 15 minutes later, the success or failure of lip anesthesia is recorded. During the treatment, the amount of pain is determined in groups. Intervention 2: Intervention group 2: Meloxicam 15 mg capsules (Iran Daru Pharmaceuticals) will be used one hour before the root canal treatment. Before starting the treatment, their pain level is recorded. One hour after the oral administration of the capsule, all patients are under lidocaine and epinephrine anesthesia. 15 minutes later, the success or failure of lip anesthesia is recorded. During the treatment, the amount of pain is determined in groups. Intervention 3: Placebo group: A lactose powder capsule (prepared by the pharmacist) will be used one hour before root canal treatment. Before starting the treatment, their pain level is recorded. One hour after the oral administration of the capsule, all patients are under lidocaine and epinephrine anesthesia. 15 minutes later, the success or failure of lip anesthesia is recorded. During the treatment, the amount of pain is determined in groups. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Mohammad Forough Reyhani
Golgasht St., Tabriz University of Medical Sciences
Tabriz Iran (Islamic Republic of) 5166614711 +98 44 3344 4598 moh_reyhani@yahoo.com Tabriz University of Medical Sciences scientific Mohammad Forough Reyhani
Golgasht St., Tabriz University of Medical Sciences
Tabriz Iran (Islamic Republic of) 5166614711 +98 44 3344 4598 moh_reyhani@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Systemically healthy A history of spontaneous, or severe pain during cold testing Age 20-40 years 20 years 40 years Both Suffering from systemic diseases Allergy to one of the following: Lidocaine, Epinephrine, NSAIDs, Dexamethasone, Caffeine Suffering from asthma, coagulation disorder, nervous and mental disorder, diseases of immune system defects Pregnancy and breastfeeding for women Allergy to the anesthetic Having a heart pace-maker K02 Dental caries Treatment - Drugs Treatment - Drugs Treatment - Other Intervention group 1: Ibuprofen capsule 800 mg (Reha Pharmaceuticals) will be used one hour before root canal treatment. Before starting the treatment, their pain level is recorded. One hour after the oral administration of the capsule, all patients are under lidocaine and epinephrine anesthesia. 15 minutes later, the success or failure of lip anesthesia is recorded. During the treatment, the amount of pain is determined in groups. Intervention group 2: Meloxicam 15 mg capsules (Iran Daru Pharmaceuticals) will be used one hour before the root canal treatment. Before starting the treatment, their pain level is recorded. One hour after the oral administration of the capsule, all patients are under lidocaine and epinephrine anesthesia. 15 minutes later, the success or failure of lip anesthesia is recorded. During the treatment, the amount of pain is determined in groups. Placebo group: A lactose powder capsule (prepared by the pharmacist) will be used one hour before root canal treatment. Before starting the treatment, their pain level is recorded. One hour after the oral administration of the capsule, all patients are under lidocaine and epinephrine anesthesia. 15 minutes later, the success or failure of lip anesthesia is recorded. During the treatment, the amount of pain is determined in groups. The amount of pain. Timepoint: Before and during root canal treatment. Method of measurement: Visual Analogue Scale. Tabriz University of Medical Sciences Approved 2022-08-29 Ethics Committee of Tabriz University of Medical Sciences Golgasht St., Tabriz University of Medical Sciences Tabriz East Azarbaijan Iran (Islamic Republic of)