IRCT20220806055626N1 IRCT 2023-01-08 Ahvaz University of Medical Sciences Comparison the Effect of Three Different Type of Treatment in Patients Being Treated for Vitiligo Lesions: 1. Microneedling, 2. Microneedling with Topical Fluocinolone and 3. Microneedling with 5-FU Comparison the Effect of Three Different Type of Treatment in Patients Being Treated for Vitiligo Lesions: 1. Microneedling, 2. Microneedling with Topical Fluocinolone and 3. Microneedling with 5-FU 2022-12-21 anticipated 20 Complete https://irct.ir/trial/65609 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Vitiligo. Intervention 1: Control group: The combination of microneedling and fluocinolone; In this group, dermapen cartridge 36 (Dr.Pen brand) microneedling with a thickness of 1.5 mm is performed once a week until Pinpoint Bleeding occurs, and after that the patient uses fluocinolone 0.025% cream twice a day. Intervention 2: Intervention group: Microneedling; In this group, microneedling is performed only once a week. Before performing the process of all three patches, the lesion site is numbed for 20 minutes after sterilizing with 70% alcohol using lidocaine cream. Intervention 3: Intervention group: Combination of microneedling and topical fluorouracil; In this group, microneedling is performed once a week, and immediately after microneedling, 5% FU cream is applied on the surface of the lesion as a thick layer, then the lesion is covered with a closed dressing for 24 hours. After opening the dressing, the desired area is washed and cleaned. Also, the patient uses 5-FU cream topically on the lesion once a day. The duration of treatment for each person is three months, during which the patient undergoes microneedling 12 times with 5-FU cream. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information