IRCT20220828055810N1 IRCT 2022-11-11 Ahvaz University of Medical Sciences Effect of pomegranate seed extract in rheumatoid arthritis Evaluating the efficacy of capsules containing pomegranate seed extract in improving the symptoms of patients with rheumatoid arthritis 2022-12-22 anticipated 60 Complete https://irct.ir/trial/65524 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be assigned into two groups by simple randomization method. Allocation of patients to the study groups will be done by random numbers generation and using computer by excel software. Random numbers will be generated in Excel with RAND function [(=RAND()*(60)] and with this function 60 random numbers will be created in the range of 1 to 60 in a column. Each patient will be assigned a two-digit code from 01 to 60. From the beginning of the first row, move down the column of random numbers and check the first two digits of the random numbers. The first 30 people seen in our code range will be placed in the first group (intervention) and the second 30 people will place in the second group (control). A person from hospital staff, who will not responsible for patient selection, enrollment, or treatment allocation, performs the randomization. The implementation of the random allocation sequence occurs without knowledge of which patient will receive which treatment, Blinding description: Intervention (receiving capsules containing pomegranate seed extract or placebo) and patient evaluation will be carried out by a physician who is blinded to both treatment groups. Drug and placebo will be in similar shape, color, and taste and prepare in same capsules. Also patients and statistical analyzer will not know about patient grouping. For blinding patients, the drug and placebo are provided to patients in similar containers, which only the serial number are mentioned. At the end of the study, the serial is converted to groups A and B in Excel software. After doing statistical analysis it will be determines which group is drugs or placebo. 3 Rheumatoid Arthritis. Intervention 1: Intervention group: The patients will be received conventional drugs including 0.2 mg/kg/week methotrexate, 5 mg prednisolone 2 times a day and 200 mg pomegranate seed extract capsule 2 times a day for 2 months. The capsule containing 200 mg of pomegranate seed extract will be prepared at the Faculty of Pharmacy of Ahvaz University of Medical Sciences. Intervention 2: Control group: The patients will be received conventional drugs including will be received 0.2 mg/kg/week methotrexate, 5 mg prednisolone 2 times a day and placebo capsule 2 times a day for 2 months. The Placebo capsules (containing Contains starch, lactose and Avicel) will be prepared at the Faculty of Pharmacy of Ahvaz University of Medical Sciences. The appearance of the drug and placebo will be same. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.