IRCT20220810055657N1 IRCT 2022-09-03 Kashan University of Medical Sciences nvestigate the effect of fluoxetine and Citalopram on motor performance after stroke in acute stroke patients Investigate the effect of fluoxetine and Citalopram on motor performance after stroke in acute stroke patients 2022-03-21 anticipated 90 Complete https://irct.ir/trial/65439 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method of randomization will be as follows: using the block randomization method (permuted block randomization) in such a way that first all 4 combinations of letters A and B are written (6 blocks) and numbers 1 to 6 for each block. considered and by randomly choosing numbers 1 to 6 from the table of random numbers; Its corresponding blocks will be written. This process of selection continues until the number of letters A and B reaches the required number of samples. After entering the study and completing the written consent form, the patient will receive a numerical code from 1 to 100 and from the table Prepared, which is available to the project manager, corresponding to the numerical code assigned to one of the drugs A or B. A and B groups will be randomly assigned to either fluoxetine or citalopram. It should be noted that regarding the variables of primary disability severity and other factors affecting the functional score, given that this study will be a clinical trial, randomization can largely control known or unknown confounding factors. (Due to the large sample size) statistical modeling also controls the effect of these factors on the outcome of the disease, Blinding description: To blind, both drugs are in the form of capsules and will be filled and coded by the neurology resident in bottles that are identical in appearance; these codes will be entered into a table and will be decoded only after the end of the study, so the patient and The doctor will not know the type of medicine received and the treatment group. 3 Acute stroke. Intervention 1: Control group: Participants will receive capsules containing microcrystalline cellulose as a placebo orally once a day for 90 days along with physical therapy one hour a day, 5 days a week, for 21 weeks. Intervention 2: Intervention group: A. Participants will receive capsules containing 20 mg of fluoxetine orally once daily for 90 days, along with physical therapy sessions of one hour per day, 5 days per week, for 21 weeks. Intervention 3: Intervention group: B . Participants will receive capsules containing 20 mg of citalopram orally once daily for 90 days along with physical therapy 1 hour per day, 5 days per week, for 21 weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.