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IRCT20220819055745N1 IRCT 2022-11-15 Tehran University of Medical Sciences Effect of transcranial direct current stimulation of different brain areas on postural adaptation Comparison of the effectiveness of transcranial electrical stimulation of the cerebellum, parietal, anterior cingulate and primary motor cortex on adaptation to postural perturbations in healthy adults: Linear and nonlinear approaches 2022-11-22 anticipated 75 Complete https://irct.ir/trial/65369 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Permuted Block Randomization method from the website randomization.com will be used for allocating participants to different groups. The size of each block will be 10. A secretary will announce the participant group via a sealed envelope for allocation concealment, Blinding description: To blind participants, there will be a sham control group. To blind the assessor, the therapist that will set the device for stimulation will be different from the therapist who will assess and collect data. 3 Postural adaptation. Intervention 1: First intervention group: This group will receive Transcranial Direct Current Stimulation on posterior parietal cortex by Star Stim device. The amplitude will be 1 milliampere and the duration of stimulation will be 20 minutes. Intervention 2: Second intervention group: This group will receive Transcranial Direct Current Stimulation on cerebellum by Star Stim device. The amplitude will be 1 milliampere and the duration of stimulation will be 20 minutes. Intervention 3: Third intervention group: This group will receive Transcranial Direct Current Stimulation on primary motor cortex by Star Stim device. The amplitude will be 1 milliampere and the duration of stimulation will be 20 minutes. Intervention 4: Forth intervention group: This group will receive Transcranial Direct Current Stimulation on anterior cingulate cortex by Star Stim device. The amplitude will be 1 milliampere and the duration of stimulation will be 20 minutes. Intervention 5: Sham control group: Second intervention group: This group will receive Transcranial Direct Current Stimulation on any random cite from the intervention groups by Star Stim device. The amplitude will be 1 milliampere and will stop after ramp-up. The ramp-up time is 10 seconds. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No decision has been made regarding it.
public Nastaran Bahadorani
Tehran university of medical science school of rehabilitation, Enghelab street
Tehran Iran (Islamic Republic of) 6511111489 +98 21 6694 5185 nbahadorani@razi.tums.ac.ir Tehran University of Medical Sciences scientific Roya Khanmohammadi
Tehran university of medical science school of rehabilitation, Enghelab street
Tehran Iran (Islamic Republic of) 6511111489 +98 21 7753 3939 rkhanmohammadi@sina.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Healthy people Age 18-40 No history of sever neurologic or musculoskeletal disorders based on the participant's clam Not having cognitive disorder (Mini-Mental State Exam (MMSE) ≥24) No wound or scratch on the scalp No sensory disorder No metal or implant in head No skin infection No pacemaker No history of epilepsy 18 years 40 years Both Taking any medication that influence balance, neural system or brain. Heavy bodily exertion before experiment Not willing to continue the study Rehabilitation Rehabilitation Rehabilitation Rehabilitation Rehabilitation First intervention group: This group will receive Transcranial Direct Current Stimulation on posterior parietal cortex by Star Stim device. The amplitude will be 1 milliampere and the duration of stimulation will be 20 minutes. Second intervention group: This group will receive Transcranial Direct Current Stimulation on cerebellum by Star Stim device. The amplitude will be 1 milliampere and the duration of stimulation will be 20 minutes. Third intervention group: This group will receive Transcranial Direct Current Stimulation on primary motor cortex by Star Stim device. The amplitude will be 1 milliampere and the duration of stimulation will be 20 minutes. Forth intervention group: This group will receive Transcranial Direct Current Stimulation on anterior cingulate cortex by Star Stim device. The amplitude will be 1 milliampere and the duration of stimulation will be 20 minutes. Sham control group: Second intervention group: This group will receive Transcranial Direct Current Stimulation on any random cite from the intervention groups by Star Stim device. The amplitude will be 1 milliampere and will stop after ramp-up. The ramp-up time is 10 seconds. Standard Deviation of Center of Pressure Displacement: This parameter comes from the second root of the sum of the square of the distance of each center of pressure from the average center of pressure divided by the number of the center of pressure in the anterior-posterior and lateral axis. The scale is in millimeter. Timepoint: Before and after the intervention. Method of measurement: Force Plate. Range of Center of Pressure Displacement: The difference between the maximum and minimum center of pressure displacement in the anterior-posterior and lateral axis. The scale is in millimeters. Timepoint: Before and after the intervention. Method of measurement: Force Plate. Path Length of Center of Pressure Displacement: This parameter comes from the summation of the distance of every center of pressure point from the consecutive point in the anterior-posterior and lateral axis. The scale is in millimeters. Timepoint: Before and after the intervention. Method of measurement: Force Plate. Lyapunov Exponent: Lyapunov Exponent is used to define the system chaos. When consecutive points diverge (divergence) the system will become chaotic, which can be quantified by Lyapunov Exponent. Timepoint: Before and after the intervention. Method of measurement: To calculate, the Rosenstein algorithm will be used in Chaos Data Analyzer Software. Approximate Entropy: Approximate Entropy is a scale for showing the complexity, regularity, and predictability of the center of pressure time series. In another word, Entropy gives a probability of the existence of a repeatable pattern with the length of m, the similarity of r, and delay of T. Timepoint: Before and after the intervention. Method of measurement: To calculate, the Pincus algorithm will be used in Matlab Software. Correlation Dimension: Correlation Dimension is a scale that shows degrees of freedom or the dimensions of the time series of the center of pressure. Timepoint: Before and after the intervention. Method of measurement: To calculate, the Grassberger and Procaccia algorithm will be used in Chaos Data Analyzer Software. Tehran University of Medical Sciences Approved 2022-08-17 Research ethics committees of school of nursing and midwifery and rehabilitation of Tehran universit Tehran university of medical science school of rehabilitation, Enghelab street Tehran Tehran Iran (Islamic Republic of)