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IRCT20220516054869N2 IRCT 2022-08-08 Zahedan University of Medical Sciences Comparison of the effect of oral captopril with sublingual captopril in lowering blood pressure in patients with acute high blood pressure Comparison of the effect of oral captopril with sublingual captopril in lowering blood pressure in patients with acute high blood pressure 2022-09-23 anticipated 138 Complete https://irct.ir/trial/65131 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation of patients to two groups is done by permuted block stratified randomization method designed with Random allocation software. In this way, first, eligible referring patients are classified according to age and gender in the order of entry. Then they are assigned to the desired group based on blocks of 4 (consisting of two groups A and B and two repetitions for each) randomly selected from among all the possible states of permutations. In order to hide the random allocation, envelopes will be used in the package, Blinding description: In this research, the triple-blind method is used. The patients will receive both forms of administration (sublingual and oral) with drugs and placebo and will be blinded to being in the intervention or control group. The data collector measures the desired outcomes and does not know which group the patient is in. The data analyst compares two groups coded A and B and is blinded to the control and intervention groups. . 3 Acute hypertension. Intervention 1: Intervention group:Sublingual captopril of Exir pharmaceutical company 25 mg once after entering the study. Intervention 2: Control group: Oral captopril 25 mg of Exir pharmaceutical company is prescribed to the patient after entering the study. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after de-identifying individuals When: The access period starts 12 months after the results are published To whom: Seas of documents will be available for researchers working in academic and scientific institutions Conditions: For medical purposes, pharmaceutical companies can receive data analysis after sending a request. Where to obtain: Applicants should write to the following postal address. ali.abdorazzagh@gamil.com How to obtain: After sending the request to the said postal address, as well as stating the purpose of accessing the data and documents, the applicant will receive the documents within a period of 12 weeks, if there is no conflict with the codes of medical ethics. Comments:
public Ali Abdolrazaghnejad
Khatam Square - Khatam Al Anbia Hospital - Department of Emergency Medicine
Zahedan Iran (Islamic Republic of) 9815733169 +98 54 3322 3003 ali.abdorazzagh@gmail.com Zahedan University of Medical Sciences scientific Ali Abdolrazaghnejad
Khatam Square - Khatam Al Anbia Hospital - Department of Emergency Medicine
Zahedan Iran (Islamic Republic of) 9815733169 +98 54 3322 3003 ali.abdorazzagh@gmail.com Zahedan University of Medical Sciences Iran (Islamic Republic of) Patients with systolic blood pressure above 160 or diastolic blood pressure above 100 referred to the FAST (outpatient) emergency department of Khatam Al-Anbia Hospital in 1401 18 years 65 years Both Patients who need blood pressure injection treatment and hospitalization Patients who have used blood pressure pills an hour before the visit Patients who have a history of kidney problems Patients with end organ damage Pregnancy Decreased level of consciousness I10 Essential (primary) hypertension Treatment - Drugs Treatment - Drugs Intervention group:Sublingual captopril of Exir pharmaceutical company 25 mg once after entering the study Control group: Oral captopril 25 mg of Exir pharmaceutical company is prescribed to the patient after entering the study. Decreased blood pressure by more than 10 mm Hg. Timepoint: 30, 10 and 60 minutes. Method of measurement: alpk2 300v mercury pressure gauge. Zahedan University of Medical Sciences Approved 2022-07-24 Ethics Committee of Zahedan University of Medical Sciences Dr. Hasabi Square - Zahedan University of Medical Sciences Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)