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IRCT20210217050393N3 IRCT 2022-07-28 Mashhad University of Medical Sciences Effect of supplementation beetroot capsul with or without vitamin C on oxidative stress factors in patients with chronic coronary heart disease Effect of supplementation beetroot capsul with or without vitamin C on serum fatty acids and oxidative stress factors in patients with chronic coronary heart disease. Double blind Randomized trial 2022-08-23 anticipated 90 Complete https://irct.ir/trial/64966 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block Randomization To apply randomization, the method of permuted block randomization with quadruple blocks will be used. In order to apply concealment in the randomization process, unique codes will be used on drug boxes, and the desired code will also be used by the online site. it is produced. Concealed allocation using opaque envelopes, in closed, sealed and sequential, Blinding description: Concealed allocation using opaque envelopes, in closed, sealed and sequential. Participants (lack of knowledge of intervention groups), Care providers (lack of knowledge of sample type assignment to groups), Investigator. 3 Coronary heart disease. Intervention 1: Intervention group1: 30 men and women with coronary heart disease received three 500 mg red beet capsules daily for 4 weeks each. Intervention 2: Intervention group 2 : 30 men and women with coronary heart disease received three 500 mg capsules of red beets and vitamin C daily for 4 weeks each. Intervention 3: Control group: Control group: 30 men and women with coronary heart disease received three placebo capsules a day for 4 weeks each, which is very similar in appearance and volume to the drug capsule. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Reza Rezvani
Mashhad university of medical sciences, Azadi squre
Mashhad Iran (Islamic Republic of) 99191-91778 +98 51 3841 2081 rezvanir@mums.ac.ir Mashhad University of Medical Sciences scientific Reza Rezvani
Mashhad university of medical sciences, Azadi squre
Mashhad Iran (Islamic Republic of) 99191-91778 +98 51 3841 2081 rezvanir@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) 1. Age 30 to 65 years 2. Men and women with chronic coronary artery disease 3. Willingness to participate in research 35 years 65 years Both 1. Do not consume more than 10% of capsules 2. The occurrence of any accident that affects a person's health 3. Having any acute illness during the study 4. Reluctance to continue cooperation in research 5. Body Mass Index more than 30 kg / m2 6. Acute heart accident in the past year 7.Taking any medicine outside the treatment protocol 8. Consumption of any herbal medicines 9. Allergy to red beet 10. Nitrate-containing drugs (such as nitroglycerin, isosorbide) 11. Using oral and injectable nutritional supplements for at least the last 4 months (vitamins D, C, E, calcium, magnesium, potassium and multivitamin-mineral, omega 3) 12. Disease (diabetes, kidney stones, gallstones, cancer and other chronic diseases) I25.1 Atherosclerotic heart disease of native coronary artery Treatment - Drugs Treatment - Drugs Placebo Intervention group1: 30 men and women with coronary heart disease received three 500 mg red beet capsules daily for 4 weeks each. Intervention group 2 : 30 men and women with coronary heart disease received three 500 mg capsules of red beets and vitamin C daily for 4 weeks each. Control group: Control group: 30 men and women with coronary heart disease received three placebo capsules a day for 4 weeks each, which is very similar in appearance and volume to the drug capsule. Malondialdehyde. Timepoint: At the beginning of the study and 28 days after consume red beet capsules. Method of measurement: laboratory kit. Myeloperoxidase. Timepoint: At the beginning of the study and 28 days after consume red beet capsules. Method of measurement: laboratory kit. Total antioxidant capacity. Timepoint: At the beginning of the study and 28 days after consume red beet capsules. Method of measurement: laboratory kit. Total Oxidant Status. Timepoint: At the beginning of the study and 28 days after consume red beet capsules. Method of measurement: laboratory kit. Saturated fatty acids. Timepoint: At the beginning of the study and 28 days after consume red beet. Method of measurement: Gas Chromatography. Polyunsaturated fatty acids. Timepoint: At the beginning of the study and 28 days after consume red beet. Method of measurement: Gas Chromatography. Monounsaturated fatty acids. Timepoint: At the beginning of the study and 28 days after consume red beet. Method of measurement: Gas Chromatography. Fatty acid indices. Timepoint: At the beginning of the study and 28 days after consume red beet. Method of measurement: Calculation through other fatty acids. Waist circumference. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: tape measure. Hip circumference. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: tape measure. Neck circumference. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: tape measure. Weight. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: Bioelectrical Impedance Analysis(BIA). Fat mass. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: Bioelectrical Impedance Analysis(BIA). Free fat mass. Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: Bioelectrical Impedance Analysis(BIA). Body Mass Index(BMI). Timepoint: At the beginning of the study and 28 days after the intervention. Method of measurement: Bioelectrical Impedance Analysis(BIA). Mashhad University of Medical Sciences Approved 2022-05-31 Ethics Committee of Mashhad University of Medical Sciences faculty of Medicine, East door of Ferdowsi University, Mashhad, Khorasan Razavi, Iran Mashhad Razavi Khorasan Iran (Islamic Republic of)