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IRCT20220724055546N1 IRCT 2022-08-04 Hamedan University of Medical Sciences Effect of Dapsone gel 5% in the treatment of mild to moderate acne Comparison the effect of Dapsone gel 5% and Benzoyl peroxide gel 5% in the treatment of mild to moderate acne in Sina Hospital in Hamadan 2022-08-23 anticipated 45 Complete https://irct.ir/trial/64946 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using the rule of random allocation: the number of samples allocated to each of the studied groups is equal, so that the first intervention group includes 45 people and the second intervention group also includes 45 people. 45 balls for the first intervention group and 45 balls for the second intervention group are placed in a lottery container and then the balls are randomly removed from the container without replacement and the created sequence is recorded, Blinding description: Patients will be evaluated by another specialist as part of the main researcher, and the design will be done in a blinded manner. 3 Acne. Intervention 1: Intervention group: Treatment with 5% dapsone gel twice a day for 3 months. Intervention 2: Intervention group: Treatment with 5% Benzoyl peroxide once a day for 3 months. Yes - There is a plan to make this available What will be shared: All data is transient after de-identifying individuals When: Access starts 6 months after the results are published To whom: Researchers working in medical institutions Conditions: Evaluation of drug effect based on age and sex Where to obtain: Hamedan University of Medical Sciences How to obtain: Request from the university research unit Comments:
public Javad Rezaiefard
Mirzadeh Eshghi Blvd., Hamedan Town, Sina hospital
Hamedan Iran (Islamic Republic of) 6516848741 +98 81 3827 4191 Javad.rzf@gmail.com Hamedan University of Medical Sciences scientific Javad Rezaiefard
Mirzadeh Eshghi Blvd., Hamedan Town, Sina hospital
Hamedan Iran (Islamic Republic of) 6516848741 +98 81 3827 4191 Javad.rzf@gmail.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Patient with mild to moderate acne 12 years no limit Both Pregnant and lactating women Known sensitivity to dapsone gel or benzoyl peroxide gel or preservatives in the drug History of using systemic drugs in the previous 3 months History of using topical antibiotics or retinoid compounds in the previous 1 month History of using antibacterial soaps or topical exfoliants in the previous 2 weeks L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: Treatment with 5% dapsone gel twice a day for 3 months Intervention group: Treatment with 5% Benzoyl peroxide once a day for 3 months Acne severity based on the global acne grading system. Timepoint: At the beginning of the treatment, one, two and three months after the treatment. Method of measurement: Global Acne Grading System. Hamedan University of Medical Sciences Approved 2022-06-27 Ethics Committee of Hamadan University of Medical Sciences Mirzadeh Eshghi Blvd., Hamedan town, Sina Hospital Hamedan Hamadan Iran (Islamic Republic of)