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IRCT20220712055439N1 IRCT 2022-08-03 Mazandaran University of Medical Sciences Evaluation of N-Acetyl Cysteine mouthwash in preventing the occurrence of chemotherapy-induced oral mucositis Evaluation of the effectiveness of N-Acetyl Cysteine mouthwash in preventing the occurrence of chemotherapy-induced oral mucositis in cancer patients referred to Imam Khomeini Hospital in Sari 2022-07-23 anticipated 68 Complete https://irct.ir/trial/64800 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: The random block method will be used to allocate the samples to two groups. Blocks will be considered as 4 blocks. Therefore, 17 blocks are needed to perform this study. Group type selection for each person will be done through the following site. www.sealedenvelope.com/simple-randomiser/v1/lists, Blinding description: Mouthwash is provided to patients in similar containers with specific codes by the Pharmaceutics Department of the Faculty of Pharmacy, and the examiner, clinical caregivers and the patient do not know the type of mouthwash. 3 chemotherapy-induced oral mucositis. Intervention 1: Intervention group: The intervention group has 34 people and uses N-acetylcysteine ​​mouthwash in the amount of 15 ml twice a day for 30 seconds for 14 days. Intervention 2: Control group: The control group also includes 34 patients who use placebo mouthwash in the amount of 15 ml twice a day for 14 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Protecting people's privacy
public Anahita Ghorbani
No 10, Mahdie 20th Alley, Mahdie St.
Sari Iran (Islamic Republic of) 4818867479 +98 11 3326 3409 anahita1802@yahoo.com Mazandaran University of Medical Sciences scientific Anahita Ghorbani
No 10, Mahdie 20th Alley, Mahdie St.
Sari Iran (Islamic Republic of) 4818867479 +98 11 3326 3409 anahita1802@yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Cancer patients undergoing chemotherapy for the first time Patients who do not have other systemic diseases no limit no limit Both Patients who have other systemic diseases Taking antibiotics, drugs, cigarettes and other mouthwashes K12.3 Oral mucositis (ulcerative) Prevention Placebo Intervention group: The intervention group has 34 people and uses N-acetylcysteine ​​mouthwash in the amount of 15 ml twice a day for 30 seconds for 14 days. Control group: The control group also includes 34 patients who use placebo mouthwash in the amount of 15 ml twice a day for 14 days. Intensity of Mucositis. Timepoint: During the 14 days of the study (from the first day to the fourteenth day after the start of chemotherapy). Method of measurement: The oral diseases specialist performs the examination based on the classification of the oral mucositis index and records the results in the classification. Mazandaran University of Medical Sciences Approved 2022-06-07 Ethics committee of Mazandaran University of Medical Sciences No. 10, Mahdie 20th Alley, Mahdie St. Sari Mazandaran Iran (Islamic Republic of)