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IRCT20200825048515N56 IRCT 2022-07-17 Esfahan University of Medical Sciences Comparison of administration of low dose ketamine with lidocaine on changes in heart rate and blood pressure during intubation A comparative study of administration of low dose ketamine with lidocaine on changes in heart rate and blood pressure during tracheal intubation under general anesthesia. 2022-08-22 anticipated 90 Complete https://irct.ir/trial/64763 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, 90 eligible patients are randomly selected. For this, the letter A is written on 30 sheets, the letter B is written on 30 sheets, the letter C is written on 30 sheets, and each of them is placed in an envelope. Each patient is then asked to choose one of the envelopes. Depending on the selected envelope, the patient is assigned to one of three groups, Blinding description: In order to achieve the triple-blind study, low dose of ketamine, lidocaine, and placebo will be prepared daily by the operating room nurse (without the researcher's awareness) and placed in the bag and will be labeled A, B, and C. And is given daily to the anesthesiologist (researcher). Therefore, the patient, the Investigator, the person recording the clinical and basic information of the patients as well as the statistical analyst will not be aware of the type of intervention. 3 Candidate patients for surgery under general anesthesia. Intervention 1: First intervention group: patients in this group receive 0.5 mg/kg of ketamine. Intervention 2: Second intervention group: patients in this group receive 0.5 mg/kg of lidocaine. Intervention 3: Control group: patients in this group do not receive any of the cases of ketamine or lidocaine (half a cc of normal saline is prescribed). No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.
public Behzad Nazemroaya
Anesthesiology Department, Isfahan Al-Zahra Hospital.
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 behzad_nazem@med.mui.ac.ir Esfahan University of Medical Sciences scientific Behzad Nazemroaya
Anesthesiology Department, Isfahan Al-Zahra Hospital.
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 behzad_nazem@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Age group 18 to 65 years American Society of Anesthesiologists (ASA) classification equal to one or two Candidate for elective and emergency surgeries under general anesthesia Consent to participate in the study 18 years 65 years Both Having a history of severe cardiovascular disease Having a history of arrhythmia Having a history of taking blood pressure lowering drugs Treatment - Drugs Treatment - Drugs Placebo First intervention group: patients in this group receive 0.5 mg/kg of ketamine. Second intervention group: patients in this group receive 0.5 mg/kg of lidocaine. Control group: patients in this group do not receive any of the cases of ketamine or lidocaine (half a cc of normal saline is prescribed). Blood pressure. Timepoint: in basic times (before induction of anesthesia, anesthesia, before tracheal tube removal) and 1, 3, 5, and 10 minutes after tracheal tube removal. Method of measurement: Monitoring device. Heart beat. Timepoint: in basic times (before induction of anesthesia, anesthesia, before tracheal tube removal) and 1, 3, 5, and 10 minutes after tracheal tube removal. Method of measurement: Monitoring device. Isfahan University of Medical Sciences Approved 2022-01-01 Ethics committee of Isfahan University of Medical Sciences Street address Isfahan University of Medical Sciences, Hezar Jarib Ave., Azadi Sq Isfahan Isfehan Iran (Islamic Republic of)