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IRCT20220516054874N3 IRCT 2022-07-17 Mashhad University of Medical Sciences Evaluation of the effect of Portulaca oleracea L. seed extract in patients with myocardial infarction Evaluation of the effectiveness of Portulaca oleracea L. seed extract on the hs CRP level in patients with myocardial infarction 2023-04-04 anticipated 68 Complete https://irct.ir/trial/64712 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The blocked randomization method is used. The volume of each block will be four. Then the list of blocks is written and numbers assigned to them, for example (AABB(1)- BBAA(2)- BABA(3)- BAAB(4)), which will be 17 blocks according to the sample size of 68. Then random numbers between 1 and 17 are selected according to the randomization site Randomaization.com and finally, the treatment allocation list is determined based on the random numbers, Blinding description: Using sealed envelopes Due to the use of a placebo similar to the intervention treatment, the investigator and the participants will not be informed of the assigned treatment, and the analyst will also be unaware of the assigned treatment for the two groups. Finally, after analyzing the data, the researcher who prepared the packages will reveal the codes A and B. 2 Myocardial infarction. Intervention 1: Intervention group: MI patients receiving Portulaca oleracea L. seed extract 300 mg twice daily for one month along with standard treatment. Intervention 2: Control group: MI patients receiving placebo capsule twice daily for one month along with standard treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available
public Dr. Vafa Baradaran Rahimi
Ghaeem hospital, Ahmadabad Blvd, Mashhad
Mashhad Iran (Islamic Republic of) 9177948564 0095 5138012739 baradaranrv@mums.ac.ir Mashhad University of Medical Sciences scientific Dr. Vafa Baradaran Rahimi
Ghaeem hospital, Ahmadabad Blvd, Mashhad
Mashhad Iran (Islamic Republic of) 9177948564 0095 5138012739 baradaranrv@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Patients with MI according to the American College of Heart criteria Consent to admission to the study Age more than 18 years old No kidney failure under hemodialysis No kidney failure and GFR<30 No thrombocytopenia No severe liver failure with liver enzymes three times more than normal No treatment with corticosteroids or immunosuppressive drugs No treatment with diltiazem or verapamil 18 years no limit Both Lack of consent to continue the study I21 ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction Treatment - Drugs Placebo Intervention group: MI patients receiving Portulaca oleracea L. seed extract 300 mg twice daily for one month along with standard treatment Control group: MI patients receiving placebo capsule twice daily for one month along with standard treatment Changes in hs-CRP serum level. Timepoint: At the beginning of the study and after 4 weeks of treatment. Method of measurement: Laboratory kit. Changes in CBC diff. Timepoint: At the beginning of the study and after 4 weeks of treatment. Method of measurement: Laboratory kit. Changes in lipid profile. Timepoint: At the beginning of the study and after 4 weeks of treatment. Method of measurement: Laboratory kit. Changes in Interleukin-6 level. Timepoint: At the beginning of the study and after 4 weeks of treatment. Method of measurement: Laboratory kit. Mashhad University of Medical Sciences Approved 2022-05-17 Ethic's committee of Mashhad University of Medical Sciences Qurashi Building, Next to Hoveyzeh Cinema, University Street, Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)