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IRCT20160307026950N42 IRCT 2022-07-13 Esfahan University of Medical Sciences Comparison of changes in Neutrophil-to-Lymphocyte Ratio (NLR) in patients with nausea vomiting and patients without nausea vomiting NLR Comparison of changes in Neutrophil-to-Lymphocyte Ratio (NLR) in patients with nausea vomiting and patients without nausea vomiting after spinal anesthesia 2022-07-23 anticipated 80 Complete https://irct.ir/trial/64655 observational Randomization: N/A, Blinding: Triple blinded, Placebo: Not used, Assignment: Single, Purpose: Diagnostic, Other design features: In this study, 80 patients are considered and examined to determine how many patients have nausea and vomiting during the study, Blinding description: This is a three-way blind clinical trial so that before obtaining consent, the patients are included in the study, but the patient does not know which people are included in the study, and it is assumed that the conditions are the same for everyone, the samples are also inside the tube. Identical forms that only have the characteristics and code of the patient group are placed so that the laboratory experts are also kept blind, those responsible for collecting data, and those who evaluate the outcome also do not know about the patient group are blind. 2 Nausea and vomiting. Intervention group: In this study, all 80 eligible patients are monitored after spinal surgery and their symptoms are recorded. Also, before and after spinal surgery and when entering recovery, cbc blood samples are taken from the patient to measure the Neutrophil to Lymphocyte Ratio. Then, in recovery, they are checked for nausea and vomiting, and if they had nausea and vomiting, the fourth sample is taken immediately after, otherwise, when they are discharged from recovery.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Mahmud Falamarz Fuladi
Hezar Jarib
Isfahan Iran (Islamic Republic of) 8146713543 +98 31 3620 2020 Leylarafiei943@gmail.com Esfahan University of Medical Sciences scientific Behzad Nazem roaya
Hezar Jarib
Isfahan Iran (Islamic Republic of) 8146713543 +98 31 3620 2020 behzad_nazem@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients 18 to 60 years old Anesthesia class I and II according to ASA criteria Candidate for surgery under spinal anesthesia Informed consent to enter the study 18 years 65 years Both BMI (Body Mass Index)>30 Cardiovascular diseases and hemodynamic disorders Use of psychotropic or sedative drugs Addiction to opioid and non-opioid drugs Pregnancy and breastfeeding Having diabetes, orthostatic hypotension, bradycardia, hypokalemia, hypothyroidism, depression, long QT syndrome R11 Nausea and vomiting Diagnosis Intervention group: In this study, all 80 eligible patients are monitored after spinal surgery and their symptoms are recorded. Also, before and after spinal surgery and when entering recovery, cbc blood samples are taken from the patient to measure the Neutrophil to Lymphocyte Ratio. Then, in recovery, they are checked for nausea and vomiting, and if they had nausea and vomiting, the fourth sample is taken immediately after, otherwise, when they are discharged from recovery. Neutrophil to lymphocyte ratio. Timepoint: Before spinal, 20 minutes after spinal, when entering recovery, immediately after nausea and vomiting and when discharged from recovery. Method of measurement: Venous blood sample. Blood Pressure. Timepoint: Every 10 minutes from the moment of entering the operating room until the moment of discharge from the recovery. Method of measurement: Sphygmomanometer. Heart Rate. Timepoint: From the moment of entering the operating room until the moment of discharge from the recovery. Method of measurement: Electrocardiogram. Oxygen saturation. Timepoint: From the moment of entering the operating room until the moment of discharge from the recovery. Method of measurement: Pulse Oximeter. Esfahan University of Medical Sciences Approved 2022-06-15 Ethics Committee in Biomedical Research, Isfahan University of Medical Sciences Hezar Jarib St Isfahan Isfehan Iran (Islamic Republic of)