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IRCT20220702055335N2 IRCT 2022-09-06 Vice chancellor for Research,Tabriz University Of Medical Sciences Evaluation of the effect of Dual Follicle Stimulating Hormone(FSH)/Human Chorionic Gonadotropin hormone(HCG) triggering on the success rate ofIntrauterine insemination (IUI) in couples diagnosed with unexplained infertility. Evaluation of the effect of Dual FSH/HCG triggering on the success rate of IUI in couples diagnosed with unexplained infertilityEvaluation of the effect of Dual Follicle Stimulating Hormone(FSH)/Human Chorionic Gonadotropin hormone(HCG) triggering on the success rate ofIntrauterine insemination (IUI) in couples diagnosed with unexplained infertility. 2022-08-27 anticipated 80 Complete https://irct.ir/trial/64557 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization and blinding will be done using the RANDOM.ORG website.Thus, for each patient, a number from 1 to 80 will be given And then, it will be obtained by the relevant site and by entering the range of random numbers.The obtained numbers will be assigned equally to two groups, Blinding description: Patients will be divided randomly into two groups (A and B).The data collection form will be provided to the analyzer with the header A and B without mentioning the type of method performed on the patient. The results of the data analysis, will be provided to the analyst without mentioning the name of the method (group A and B) to examine the consequences.So, these people will be blinded. 3 Female infertility. Intervention 1: Intervention group: after checking the state of the ovaries and ensuring the presence of at least one mature follicle larger than 18 mm (between one and five follicles) and a suitable endometrium with a thickness of at least 7 mm, two ampoules of human chorionic gonadotropin hormone(HCG) 5000 intramuscular units (manufactured by Poyesh Pharmaceutical Company Daru, Iran) along with 150 units of (follicle stimulating hormone) FSH (Two ampoules of 75 units of Cinnal F) (manufactured by Shafayab Gostar Company) are also received subcutaneously. 34 to 36 hours later, Intrauterine insemination (IUI) is performed as usual. Intervention 2: Control group: after checking the state of the ovaries and ensuring the presence of at least one mature follicle larger than 18 mm (between one and five follicles) and a suitable endometrium with a thickness of at least 7 mm, two ampoules of human chorionic gonadotropin hormone(HCG) 5000 intramuscular units (manufactured by Poyesh Pharmaceutical Company) Daru, Iran) will be injected intramuscularly. 34 to 36 hours later, Intrauterine insemination (IUI) is performed as usual. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After the completion of the project, the decision will be made.
public Dr.Parvin Hakimi
Tabriz University Of Medical Sciences, Golgasht Street
Tabriz Iran (Islamic Republic of) 5138665793 +98 35519161 lahroudin@gmail.com Tabriz University of Medical Sciences scientific Dr.Parvin Hakimi
Tabriz University Of Medical Sciences, Golgasht Street
Tabriz Iran (Islamic Republic of) 5138665793 +98 35519161 lahroudin@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Having an informed consent to participate in the study Unexplained infertility diagnosis The health of the uterus structure Normal pap smear test Normal sperm analysis Women between 20 and 38 years old 20 years 38 years Female Moderate to severe endometriosis Hyper prolactinemia Hyperthyroidism Hypothyroidism Ovarian Cysts Kidney and liver failure Secondary infertility N97.9 Female infertility, unspecified Treatment - Drugs Treatment - Drugs Intervention group: after checking the state of the ovaries and ensuring the presence of at least one mature follicle larger than 18 mm (between one and five follicles) and a suitable endometrium with a thickness of at least 7 mm, two ampoules of human chorionic gonadotropin hormone(HCG) 5000 intramuscular units (manufactured by Poyesh Pharmaceutical Company Daru, Iran) along with 150 units of (follicle stimulating hormone) FSH (Two ampoules of 75 units of Cinnal F) (manufactured by Shafayab Gostar Company) are also received subcutaneously. 34 to 36 hours later, Intrauterine insemination (IUI) is performed as usual. Control group: after checking the state of the ovaries and ensuring the presence of at least one mature follicle larger than 18 mm (between one and five follicles) and a suitable endometrium with a thickness of at least 7 mm, two ampoules of human chorionic gonadotropin hormone(HCG) 5000 intramuscular units (manufactured by Poyesh Pharmaceutical Company) Daru, Iran) will be injected intramuscularly. 34 to 36 hours later, Intrauterine insemination (IUI) is performed as usual. Clinical pregnancy rate. Timepoint: 28 days after transfer. Method of measurement: Vaginal sonography. Chemical pregnancy rate. Timepoint: 14 days after transfer. Method of measurement: BhCG test. Vice chancellor for Research,Tabriz University Of Medical Sciences Approved 2022-06-01 Ethics Committee Of Tabriz University Of Medical Sciences Third Floor, Central Building of Number2, Golgasht Street Tabriz East Azarbaijan Iran (Islamic Republic of)