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IRCT20220702055334N1 IRCT 2022-07-11 Kashan University of Medical Sciences Effect of vitamin D on short-term prognosis of acute ischemic stroke Effect of vitamin D on short-term prognosis of acute ischemic stroke 2022-07-23 anticipated 40 Complete https://irct.ir/trial/64550 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: First, the intervention group was coded with the letter A and the control group with the letter B, and then using the website www. sealedenvelope.com/simple-randomiser/v1/lists randomization list was prepared by selecting a sample size of 40 (two groups of 20) and permuted block randomization method (block size=4) (10 blocks of 4). Then, through the obtained randomization list, the subjects included in the study will be assigned to one of the two groups A or B. For example, suppose that in the first four blocks, the permutation method is ABBA, so the first and fourth samples will be assigned to group A and the second and third samples to group B and the same will continue until the last sample (40th person). 3 Acute ischemic stroke. Intervention 1: Intervention group: Intervention group patients up to 24 hours from the onset of symptoms in addition to standard treatments (including antiplatelet (aspirin 325 mg stat and 80 mg daily), lipid lowering agent (atorvastatin 80 mg acetate and 40 mg twice a day), hydration (an average of 1.5 L normal daily saline) and pantoprazole (40 mg daily) according to the conditions of each patient), are subjected to a single dose of intramuscular vitamin D injection (300,000 IU) from Osveh made in Iran. Intervention 2: Control group: Standard treatment Including antiplatelet (aspirin 325 mg stat and 80 mg daily), lipid lowering agent (atorvastatin 80 mg acetate and 40 mg twice a day), hydration (an average of 1.5 L normal daily saline) and pantoprazole (40 mg daily) according to the conditions of each patient. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Arezoo Jafarian Yazdi
Motahari Street, Mir Emad 10, No. 7, Unit 19
Tehran Iran (Islamic Republic of) 1587836151 +98 21 2256 1168 Arezoo.jafarian1991@yahoo.com Kashan University of Medical Sciences scientific Dr. Seyed Ali Massoud
Qutb Ravandi Boulevard, Shahid Beheshti Hospital
Kashan Iran (Islamic Republic of) 8715981151 +98 31 5558 9333 beheshtihospital@kaums.ac.ir Kashan University of Medical Sciences Iran (Islamic Republic of) Patients over 18 years of age with acute ischemic stroke diagnosed by clinical examination and CT scan findings 19 years no limit Both Admission after 24 hours from the onset of symptoms NIHSS >15 at admission being treated with vitamin D (at least the last 3 months) Receive alteplase History of malignancy I63 Cerebral infarction Treatment - Drugs Other Intervention group: Intervention group patients up to 24 hours from the onset of symptoms in addition to standard treatments (including antiplatelet (aspirin 325 mg stat and 80 mg daily), lipid lowering agent (atorvastatin 80 mg acetate and 40 mg twice a day), hydration (an average of 1.5 L normal daily saline) and pantoprazole (40 mg daily) according to the conditions of each patient), are subjected to a single dose of intramuscular vitamin D injection (300,000 IU) from Osveh made in Iran. Control group: Standard treatment Including antiplatelet (aspirin 325 mg stat and 80 mg daily), lipid lowering agent (atorvastatin 80 mg acetate and 40 mg twice a day), hydration (an average of 1.5 L normal daily saline) and pantoprazole (40 mg daily) according to the conditions of each patient Disability severity (MRS). Timepoint: At the beginning of the study, six weeks after the intervention. Method of measurement: MRS specific scoring system. Kashan University of Medical Sciences Approved 2022-06-19 Ethics committee of Kashan University of Medical Sciences Qutb Ravandi Boulevard - Kashan University of Medical Sciences Kashan Isfehan Iran (Islamic Republic of)