IRCT20210413050958N6 IRCT 2022-07-31 Mashhad University of Medical Sciences Effect of curcumin on cardiopulmonary efficacy The effects of curcumin on the cardiopulmonary efficacy in subjects with central obesity: A Randomized, Double-Blind, Placebo-Controlled Trial 2022-11-01 anticipated 25 Complete https://irct.ir/trial/64521 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The statistician generates a random allocation sequence using the block randomization method. So that blocks with size 4 and 2 of the combination of letters A and B (ABBA, ABAB, AABB, BAAB, BBAA, BABA), (AB and BA) are selected to the required number using a table of random numbers and individuals are assigned to groups according to the created sequence. Subjects are divided into one of two intervention/control groups using a table of random numbers, so that who enrolled the trial can select a sealed envelope with random allocation sequence to the intervention or control group. An expert outside the research team blinds the drugs. The executive team register the subjects and assign them to the intervention. All volunteers, the executive team, and the statistical analyst will be blinded by the interventions, Blinding description: The random allocation sequence is made using the table of random numbers. Sequentially numbered sealed envelopes are used to implement the random allocation sequence which opened by a person not involved in the project. The participants, care providers and statistician are blinded after assignment to intervention. So that, the powders bottles are coded by a non-researcher person and remain confidential until data analysis. Moreover, In addition, placebo powder is similar to supplement powder in shape, weight and color. 2 central obesity. Intervention 1: The treatment group (n= 25) including subjects with central obesity based on NCEP-ATP III. Curcumin (C3 complex) at a dose of 500 mg/day plus 5 mg piperine is taken orally over 8 weeks purchased from Sami Labs LTD (Bangalore, India) in the intervention group. Intervention 2: The control group includes subjects with central obesity based on NCEP-ATP III. Placebo at a dose of 500 milligram per day containing 5 mg of piperine too that purchased from Sami Labs LTD (Bangalore, India) and are the same shape and color with curcumin that is received orally by control group over 8 weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is Raw data will be shared upon a reasonable request from the corresponding author.