]>
IRCT20220626055283N1 IRCT 2022-11-30 Mashhad University of Medical Sciences Efficacy of herbal solution in androgenic alopecia treatment Comparison of topical herbal preparation with minoxidil in androgenic alopecia: double blind randomized clinical trial 2022-11-11 anticipated 60 Complete https://irct.ir/trial/64494 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be allocated to topical herbal preparation or topical minoxidil groups, by block randomization with a block size of 4. In each block, patients of each group will exist. The order of blocks will be determined randomly in topical herbal preparation or topical minoxidil groups and subjects will be allocated sequentially with the order of admitting. The random allocation rule method was used for the determination of sequences. Use non-transparent envelopes sealed with random sequences (Sequentially numbered, sealed, opaque envelopes). They are placed in order. In order to maintain the random sequence, numbering is done on the outer surface of the envelopes in the same way. Finally, the lids of the letter envelopes are glued and placed inside a box, respectively. At the beginning of the registration of participants, based on the order of entry of eligible participants in the study, one of the envelopes of the letter will be opened in order and the assigned group of the participant will be revealed, Blinding description: Patients receive drugs (intervention or control groups) in closed pockets which are coded and patients are not aware of their contents. Coding will be done by one of the colleagues of the study and the investigator physician will be blind for the type of drugs. 1 Male androgenic alopecia. Intervention 1: Intervention group:Receiving topical herbal preparation (containing extracts of Adiantum capillus-veneris 1%, Centella asitica 0.5%, Ruta graveolense 0.5%, Emblica officinalis 5%). Intervention 2: Intervention group: Receiving topical minoxidil 5%. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more data
public Seyedeh Mahdieh Toosi
Dermatology department, Imam Reza hospital, Imam Reza hospital square, Avecina street, Imam Reza hospital square, Mashhad
Mashhad Iran (Islamic Republic of) 9177899191 +98 51 3802 2031 Tousimh991@mums.ac.ir Mashhad University of Medical Sciences scientific Bita kiafar
Dermatology department, Imam Reza hospital, Imam Reza hospital square, Avecina street, Imam Reza hospital square, Mashhad
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3802 2031 Kiafarb@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) All male patient between 18-45 years old with androgenic alopecia Patient satisfaction 18 years 45 years Male Endocrine disorder Using zinc and iron supplement Renal disease Malnutrition and iron deficiency anemia Thyroid disorder Systemic disorder such as lupus Other causes of alopecia like alopecia areata and scar alopecias Using drugs lead to alopecia like anti-hypertensive agents or NSAIDs History of dermatologic or systemic malignancy Psychiatric disorders Consumption of alcohol History of consumption of finasteride within 6 months ago L64.9 Androgenic alopecia, unspecified Treatment - Drugs Treatment - Drugs Intervention group:Receiving topical herbal preparation (containing extracts of Adiantum capillus-veneris 1%, Centella asitica 0.5%, Ruta graveolense 0.5%, Emblica officinalis 5%) Intervention group: Receiving topical minoxidil 5% Hair count. Timepoint: Evaluation of hair count with trichoscopy in 0, 8, 16 , 24 weeks of trial. Method of measurement: Efficacy of herbal solution (Adiantum Capillus-veneris, Centella asitica, Rutagraveolense, Emblica officinalis) on androgenic alopecia and examine hair count with trichoscopy. Mashhad University of Medical Sciences Approved 2017-12-20 Ethics committee of Mashhad University of Medical Sciences Central Building of Mashhad University of Medical Scineces (Ghorashi), Daneshgah 16, Daneshgah street Mashhad Razavi Khorasan Iran (Islamic Republic of)