IRCT20200707048047N2 IRCT 2022-09-07 Islamic Azad University Comparison of the effect of local anesthesia induced by intradermal injection of ketamine with lidocaine in intravenous venipuncture Comparison of the effect of local anesthesia induced by intradermal injection of ketamine with lidocaine in intravenous venipuncture 2022-06-28 anticipated 246 Complete https://irct.ir/trial/64457 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: Blinding is done in such a way that ketamine, lidocaine and normal saline are poured into similar 100 ml vials and each of the letters a, b, c is written and patients are randomly divided into three groups. Depending on whether they were in groups 1,2 or 3, they will receive a coded vial, and the researcher prescribing the drug is not aware of the type of drug, and later in the statistical analysis it will be determined which drug in each group Patients Nurses and data collectors do not know the type of substance used for each patient. 3 venipuncture. Intervention 1: The first intervention procedure: 0.2 ml of buffered lidocaine, which is obtained by adding two ml of 7.5% bicarbonate to twenty-two ml of 1% lidocaine, is injected intradermally. The second intervention group: 0.2 ml of 1 mg ketamine solution will be injected intradermally. After two to three minutes, the target area will be disinfected and the vein will be removed by professional nurses who did not know about the study. All cases of venipuncture are performed using venous catheter gage 21 in the area of ​​the middle cubital vein.Ketamine is a cyclohexanone derivative used to induce anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA (N-Methyl-D-Aspartate) receptors and may interact with sigma receptors. Lidocaine is a local anesthetic and cardiac depressant that is known as Antiarrhythmic agent is used. Its action is more intense and its effects are longer than the effects of procaine, but its duration of action is shorter than that of bupivacaine or prilocaine.Three vials of lidocaine 2% (50 ml) are used at the unit price of 1471000 Rial in Shahid Ghazi pharmaceutical company, built inside. Ketamine vials of 50 mg/ml (10 ml) are three units at the unit price of 3500000 in the pharmaceutical company. Internally made elixir is used. 246 pink venous catheter are used at the unit price of 33,000 Rial made by Polymed. 246 sets of serums are used at a unit price of 55,000 Rial made by Polymed. Intervention 2: Control group: Control group: 0.2 ml of normal saline will be injected intradermally and after two to three minutes the target area will be disinfected and the vein will be removed by professional nurses who were not aware of the study. All cases of venipuncture are performed using venous catheter gage 21 in the area of ​​the middle cubital vein. Injectable normal saline is used in four units at the price of 184,800 Rial, the Iranian injectable and medicinal products. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is PATIENTS PRIVACY