IRCT20200718048125N2 IRCT 2022-12-14 Islamic Azad University The effect of adding lidocaine to morphine on pain intensity after unilateral knee prosthesis surgery PCA Evaluation of adding Lidocaine to Morphine in patient controlled analgesia on pain intensity after unilateral knee prosthesis surgery by spinal anesthesia 2022-11-27 anticipated 58 Complete https://irct.ir/trial/64380 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A simple randomization method is used. We assign an A and B code to each anesthetic intervention. With the lottery method, patients will be placed in one of two codes. In this way, 29 codes A and 29 codes B are written on the paper and each paper is placed inside a special non-transparent sealed envelope and the envelopes are randomly placed on top of each other. Upon the entry of each qualified patient, an envelope is returned by the anesthesiologist to that patient and according to the code written on the paper inside, the anesthetic method is applied, Blinding description: In this study, patients are placed in two separate groups, A and B, which have the same drug composition except for one type of drug, and drugs with the same shape and packaging are injected to the patients through a patient controlled analgesia pump. The patient does not know whether he is in the control group or the intervention group. The personnel cooperating in the plan do not know the content of the pain pump. The researcher also has no knowledge of which group each patient is in and only analyzes the information. 2-3 Osteoarthritis of knee. Intervention 1: Control group: Spinal anesthesia; 25-gauge spinal needle (Dr.J Tianjin Hanaco Medical Co. Tianjin, China) was introduced, then 0.5% Bupivacaine mixed with 0.2 mg of Adrenaline was injected at either the third or fourth lumbar epidural space with median or paramedian approach. The content of the patient controlled analgesia pump attached to the patient included 20 mg of morphine, 8 mg of Ondansetron ampoule (4 cc), 1g of Apotel (6.7 cc) and the rest of normal saline to reach a total volume of 100 cc. Intervention 2: Intervention group: Spinal anesthesia; 25-gauge spinal needle (Dr.J Tianjin Hanaco Medical Co. Tianjin, China) was introduced, then 0.5% Bupivacaine mixed with 0.2 mg of Adrenaline was injected at either the third or fourth lumbar epidural space with median or paramedian approach. The contents of the patient controlled analgesia pump include 10 mg of morphine, 50 cc of 2.8% lidocaine, 8 mg of Ondansetron ampoule (4 cc), one gram of Apotel (6.7 cc) and the rest of normal saline to reach a total volume of 100 cc. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.