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IRCT20220618055207N1 IRCT 2022-09-06 Tehran University of Medical Sciences Investigation of the effect of interalipid on aluminum phosphide poisoning Evaluation of the effect of intralipid in the treatment of patients with phosphide poisoning 2020-03-20 anticipated 60 Complete https://irct.ir/trial/64261 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomized, block- Availability sampling was used and the sample size was 60 people (30 people in each of intralipid and placebo groups). At the stage of dividing into groups, as Block randomization with blocks of 5 people were divided into intralipid and placebo groups. 2-3 Aluminium phosphide poisoning. Intervention 1: Intervention group: In addition to the usual treatment of aluminum phosphide poisoning, Serum Intralipid was administered as a bolus dose of 1.5ml/kg and maintenance dose of 0.25-0.5ml/kg/min with 20% Intralipid . Intervention 2: Control group: In addition to the usual treatment of aluminum phosphide poisoning, normal saline was administered with a bolus dose of 1.5 ml/kg and maintenance dose of 0.25-0.5 ml/kg/min. Yes - There is a plan to make this available What will be shared: demographic information and the final main outcome When: October after the results are published To whom: Researchers working in medical universities of the country Conditions: Any use of the documentation of this Research project for analysis or carrying out other plans must be done with the knowledge and coordination and obtaining permission from the main implementers of the plan. Where to obtain: By email to Dr. Mohammad Arefi How to obtain: The purpose of using the data must be completely transparent and only demographic information and the final main outcome can be sent - via email and a period of about one month. Comments:
public Dr . Mohammad Arefi
Baharloo Hospital- Beehdari Street- Railway Square- Tehran
Tehran Iran (Islamic Republic of) 13399 73111 +98 21 5565 8500 armaniair@yahoo.com Tehran University of Medical Sciences scientific Dr.Mohammad Arefi
Baharloo Hospital- Beehdari Street -Railway Square
Tehran Iran (Islamic Republic of) 13399 73111 +98 21 5565 8500 armaniair@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) aluminum phosphide poisoning Metabolic acidosis (bicarbonate less than 14) during the first 6 hours no limit no limit Both Dissatisfaction of patients simultaneous poisoning (multidrug toxicity) T57.1X2 Toxic effect of phosphorus and its compounds, intentional self-harm Treatment - Drugs Treatment - Drugs Intervention group: In addition to the usual treatment of aluminum phosphide poisoning, Serum Intralipid was administered as a bolus dose of 1.5ml/kg and maintenance dose of 0.25-0.5ml/kg/min with 20% Intralipid . Control group: In addition to the usual treatment of aluminum phosphide poisoning, normal saline was administered with a bolus dose of 1.5 ml/kg and maintenance dose of 0.25-0.5 ml/kg/min. Heart rate, systolic blood pressure, acidosis and arterial blood pH, death. Timepoint: At the beginning of the study and 24 hours after the start of the intervention. Method of measurement: Vital Sign Monitor in icu. Tehran University of Medical Sciences Approved 2019-05-04 Ethics committee of Tehran University of Medical Science Room 605 - Secretariat of the Ethics Committee in Biomedical Research of the University - Central Organization of the University, 6th Floor of the Research and Technology Vice-Chancellor - Central Organization of the University - Corner of Quds St. - Keshavarz Blvd. Tehran Tehran Iran (Islamic Republic of)