IRCT20170411033365N4 IRCT 2022-07-20 Oroumia University of Medical Sciences Assessment of the prophylactic combined effect of diphenhydramine with paracetamol on agitation and pain after laparoscopic cholecystectomy Assessment of the prophylactic combined effect of diphenhydramine with paracetamol on agitation and pain after laparoscopic cholecystectomy 2022-08-22 anticipated 30 Complete https://irct.ir/trial/64110 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Determining the prophylactic effect of diphenhydramine with paracetamol on agitation and pain after laparoscopic cholecystectomy, Randomization description: The number of patients in this study will be 60 patients. Patients will be randomly divided into two equal groups by computer numbers via a certified true randomizer number generator (www.random.org, Android Play Store) and Based on the last number of the file number .From number of 0-30 in control group and 31-60 will be placed in Diphenhydramine and Paracetamol group. Target codes will be written and placed in sealed envelops with sequential allocation using single blind method, Blinding description: In this study, the clinical caregiver and outcome assessor will be unaware of which group each patient belongs to. 3 Cholecystectomy. Intervention 1: Intervention group: In group (P), intravenous paracetamol will be injected simultaneously for more than 15 minutes (1 g of paracetamol per 100 ml of 0.9% NaCl) 10 minutes after induction of anesthesia. Intervention 2: Intervention group: In the DP group, diphenhydramine 0.4 mg / kg intravenously in 100 ml of 0.9% Nacl with paracetamol will be injected together for 10 minutes after induction of anesthesia. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I will make a decision to publish after the completion of the project and according to the results