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IRCT20180811040759N3 IRCT 2022-06-19 Rafsanjan University of Medical Sciences The effect of achillea millefolium oil on some clinical symptom of knee joint osteoarthritis: a randomized and double blind clinical trial double- blind study The effect of achillea millefolium oil on some clinical symptom of knee joint osteoarthritis: a randomized and double blind clinical trial double- blind study 2022-07-01 anticipated 81 Complete https://irct.ir/trial/64097 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using a table of random numbers, they are randomly divided into one of three groups: the treatment group (receiving achillea millefolium oil (Oil Seed Company)), the control group (paraffin) and the receiving group of piroxicam gel, Blinding description: Controlled double-blinds (patient not knowing about and completing evaluation of checklists of the type of drug used) will be performed.The duration of the massage is 3 to 5 minutes daily and the duration of taking the medicine is 2 months.The drugs are coded by someone other than the investigator and will be delivered to the Physician. Clinical examinations and confirmation of the disease are performed by a rheumatologist and subsequent evaluations are performed under the supervision of a rheumatologist and by an internal resident who will be unaware of the groups. 3 Osteoarthritis. Intervention 1: Intervention group: Group 1 (27 Individuals) will use achillea millefolium oil. The treatment duration is 2 months, massage 3 to 5 minutes daily. During the study, patients in all groups, are only allowed to use oral analgesics without anti-inflammatory effect such as acetaminophen once daily if needed. Intervention 2: Control group: Group 2 (Placebo) (27 individuals). The form and type of the drug is the same. The treatment duration is 2 months, massage 3 to 5 minutes daily. During the study, patients in all groups, are only allowed to use oral analgesics without anti-inflammatory effect such as acetaminophen once daily if needed. Intervention 3: Intervention group: Group 3 will receive Piroxicam gel. The treatment duration is 2 months, massage 3 to 5 minutes daily. During the study, patients in all groups, are only allowed to use oral analgesics without anti-inflammatory effect such as acetaminophen once daily if needed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available
public Mitra Abbasifard
Emam Ali Ave, rafsanjan university of medical sciense
Rafsanjan Iran (Islamic Republic of) 7717937555 +98 34 3428 0040 dr.mabbasifard@rums.ac.ir Rafsanjan University of Medical Sciences scientific Mitra Abbasifard
Emam Ali Ave, rafsanjan university of medical sciense
Rafsanjan Iran (Islamic Republic of) 7717937555 +98 34 3428 0040 dr.mabbasifard@rums.ac.ir Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Awareness consent to participate in the study Moderate to severe pain intensity visual linear scale of pain Age 45-70 years The diagnosis of osteoarthritis of the knee is based on the diagnostic criteria of the American College of Rheumatology and the confirmation of the rheumatologist's diagnosis by a rheumatologist Existence of moderate pain in the knee during 24 hours based on the linear-visual scale of pain between 4-7 cm 45 years 70 years Both Reluctance to continue participating in the study Non-compliance with the study protocol Observe any side effects that the patient thinks were caused by yarrow oil after the start of the study Taking vitamin, mineral or other nutritional supplements and taking painkillers M17 Osteoarthritis of knee Treatment - Drugs Placebo Treatment - Drugs Intervention group: Group 1 (27 Individuals) will use achillea millefolium oil. The treatment duration is 2 months, massage 3 to 5 minutes daily. During the study, patients in all groups, are only allowed to use oral analgesics without anti-inflammatory effect such as acetaminophen once daily if needed Control group: Group 2 (Placebo) (27 individuals). The form and type of the drug is the same. The treatment duration is 2 months, massage 3 to 5 minutes daily. During the study, patients in all groups, are only allowed to use oral analgesics without anti-inflammatory effect such as acetaminophen once daily if needed Intervention group: Group 3 will receive Piroxicam gel. The treatment duration is 2 months, massage 3 to 5 minutes daily. During the study, patients in all groups, are only allowed to use oral analgesics without anti-inflammatory effect such as acetaminophen once daily if needed. Knee pain intensity. Timepoint: At the beginning and the end of the study (two months after the beginning of the study). Method of measurement: Visual Analogue Scale (VAS) And WOMAC index. Rafsanjan University of Medical Sciences Approved 2022-04-13 Ethics Committee of Rafsanjan University of Medical Sciences Ali ibn Abi Talib Square, Ali ibn Abi Talib Hospital Rafsanjan Kerman Iran (Islamic Republic of)