IRCT20220601055051N1 IRCT 2023-02-03 Tehran University of Medical Sciences Effect of Oregano nasal spray on migraine Effect of an herbal nasal spray (an Iranian traditional medicine drug) based on oregano on migraine: A randomized, double-blinded, clinical trial 2023-02-09 anticipated 70 Complete https://irct.ir/trial/63927 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block Random Allocation Two groups A and B randomly are allocated to intervention and control groups and are again randomly used in quadruple groups each with two A and two B groups arranged in all different possible arrangement that is: AABB, BBAA, ABAB,BABA,ABBA,BAAB A and B are in sealed envelope and handed to patients; and so they are randomly entered in two groups . Randomization unit is individual, Blinding description: The procedure is clearly explained to the patients and then they are given the drugs while they have no idea which drug, the real or the placebo is given to them; so patients are blind. The investigator who hands in the drugs to the patients does not know which drugs are real and which are placebos; so the investigator is blind, too. 3 Migraine headache. Intervention 1: Intervention group: herbal nasal spray based on oregano- three times a day one puff each nasal orifice. Intervention 2: Control group: placebo nasal spray-three times a day one puff each nasal orifice. No - There is not a plan to make this available Justification or reason for not sharing IPD is there is no more information.