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IRCT20220528055005N1 IRCT 2022-06-03 Esfahan University of Medical Sciences Effect of oral minoxidil in treatment of lichen planopilaris Evaluation of the effect of adding oral minoxidil to standard anti-inflammatory therapy in the treatment of patients with lichen planopilaris 2022-06-22 anticipated 34 Complete https://irct.ir/trial/63841 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomly divided into two groups of methotrexate and oral minoxidil with methotrexate by random allocation software. 2 Lichen planopilaris. Intervention 1: Intervention group: Methotrexate ( 15 mg/week orally in one day) will be administered in one group ( 17 patients) and for 6 months. Intervention 2: Intervention group: Minoxidil 1 mg tablet in addition to methotrexate 15 mg weekly administered in the other group of 17 people for 6 months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is اطلاعات بیشتری وجود ندارد
public Dr Shaghayegh dehghani
Department of Dermatology ،Alzahra hospital، Sofe street
Isfahan Iran (Islamic Republic of) 8168613446 +98 31 3668 8644 sh_dehghanii@yahoo.com Esfahan University of Medical Sciences scientific Dr shaghayegh dehghani
Department of Dermatology ، Alzahra hospital، Sofe street
Isfahan Iran (Islamic Republic of) 8168613446 +98 31 3668 8644 sh_dehghanii@yahoo.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Newly diagnosed patients who have not yet received treatment. Patients who have previously been treated and whose disease is still active according to clinical and dermoscopic criteria Patients should have discontinued any previous systemic medication 1 month before entering the study and should not use any systemic or topical medication at the time of the study 18 years 65 years Both pregnancy or breastfeeding Leukocytes <3000 Platelets <100000 Hemoglobin <9 Liver enzymes more than 2 times the reference limit Positive for viral hepatitis tests History of cardiovascular disease and hypotension History of arrhythmia (non-sinus rhythm on ECG) L66.1 Follicular Lichen Planus Treatment - Drugs Treatment - Drugs Intervention group: Methotrexate ( 15 mg/week orally in one day) will be administered in one group ( 17 patients) and for 6 months Intervention group: Minoxidil 1 mg tablet in addition to methotrexate 15 mg weekly administered in the other group of 17 people for 6 months. Lichen planopilaris activity index. Timepoint: Befor and after intervention. Method of measurement: Cheklist. Standardized global photography. Timepoint: Befor and after intervention. Method of measurement: Based on scoring by two dermatologist. Dermoscopy. Timepoint: Befor and after intervention. Method of measurement: Chcklist. Esfahan University of Medical Sciences Approved 2022-05-25 Ethics committee of IsfahanUniversity of Medical Sciences No 38 ،second Alley، Mollasadra Ave Isfahan Isfehan Iran (Islamic Republic of)