IRCT20220220054073N1 IRCT 2023-06-27 Iran National Science Foundation (INSF) Evaluating the pain relieving effects of Non-Thermal CO2 Laser Therapy (NTCLT) on chemotherapy induced oral mucositis NTCLT Evaluating the pain relieving effects of Non-Thermal CO2 Laser Therapy (NTCLT) on chemotherapy induced oral mucositis 2015-04-21 anticipated 20 Complete https://irct.ir/trial/63766 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Other design features: Before-After Clinical Trial. 2 Chemotherapy-induced oral mucositis. Intervention group: Patients with chemotherapy-induced oral mucositis. In this before-after clinical trial, the patients were irradiated with a single session of NTCLT. At first, the surgical staff and the patient put on protective eyeglasses. Then, the lesion and its surrounding tissue were covered with a thick layer (3-4 mm) of a non-anesthetic, completely transparent gel containing very high percentage (87.5%) of water (Abzar Darman Co., Iran). (This gel is routinely used for gastrointestinal endoscopy as a lubricating agent, sonography, etc.) Before the initiation of laser irradiation, the patient and surgical staff put on appropriate safety goggles. The CO2 laser (wavelength: 10600 nm; Lancet-2, Russia) beam (power: 1 Watt, in continuous mode) was irradiated through the gel layer. The lesion was scanned with rapid circular motion of the handpiece over the lesion, while the distance of the tip of the defocused handpiece from the surface of the gel was about 5-6 mm. The laser beam was illuminated to a circle area of the lesion (with a diameter of approximately 1cm) for 5 seconds in each pass. If the contact pain of the lesion persisted, the procedure was repeated again. The gel layer was gently wiped between the passes, and a new layer of gel was placed on the lesion.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Data Privacy