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IRCT201103165900N3 IRCT 2011-04-14 Hamedan dental faculty Evaluation the effect of one stage full mouth disinfection on serum IL17 and IL23 levels in patients with moderate to severe chronic periodontitis Evaluation the effect of one stage full mouth disinfection on serum IL17 and IL23 levels in patients with moderate to severe chronic periodontitis 2010-12-06 anticipated 33 Complete https://irct.ir/trial/6372 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment, Other design features: It is a before & after study without any control group. 3 periodontitis. one-stage full mouth disinfection.
public Ali Zarandi
Periodontics department, Hamedan dental faculty
Hamedan Iran (Islamic Republic of) +98 81 1825 0498 zarandi.ali@umsha.ac.ir Hamedan dental faculty scientific Ali Zarandi
Periodontics Department, Hamedan dental faculty
Hamedan Iran (Islamic Republic of) +98 81 1825 0498 zarandi.ali@umsha.ac.ir Hamedan dental faculty Iran (Islamic Republic of) Inclusion criteria: 1- patients aged 25 to 70 years 2- Having at least 12 teeth (regardless of third molars, teeth with orthodontic appliances, crowns, bridges and implants) 3- Diagnosis of moderate to advanced chronic periodontitis 4- having informed consent. Exclusion criteria: 1- Patients with a contra-indication for surgery or local anesthesia or scaling 2- Systemic disease (eg diabetes mellitus, cancer, AIDS, metabolic bone disease, diseases that delay the healing pockets, previous radiotherapy or immunosuppressive treatment, autoimmune diseases, allergies, infectious diseases, neutropenia, bleeding disorders, Rheumatoid arthritis, bowel disease, lung disease, multiple sclerosis) 3- pregnancy or lactation 4- History of systemic antibiotics use in the past six months 5- History of continuous use of NSAIDS in the past six months 6- scaling and root planning in the past year 7- contagious diseases 8- History of smoking in the past six months 25 years 70 years Both K05.3 Chronic periodontitis Treatment - Other one-stage full mouth disinfection Serum levels of IL-17. Timepoint: 6 weeks later. Method of measurement: laboratory assessment (IL-17 ELISA kit). Serum IL-23 level. Timepoint: 6 weeks later. Method of measurement: laboratory assessment (IL-23 ELISA kit). Hamedan dental faculty Approved 2010-12-06 Ethics committee of Hamedan university of medical sciences and health services Vice chancellor for research, Hamedan University of Medical Sciences and Health Services, Fahmideh Street Hamedan Iran (Islamic Republic of)