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IRCT20170114031921N1 IRCT 2022-05-30 Hamedan University of Medical Sciences The effect of combination exercises on metabolic syndrome The effect of eight weeks combined training on the level of sirtuin1 and MicroRNA-122 in men with metabolic syndrome 2022-06-06 anticipated 30 Complete https://irct.ir/trial/63653 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance, Randomization description: Block randomization is commonly used to balance the number of samples assigned to each of the intervention and comparison groups. This feature makes the number of samples assigned to each of the study groups equal in cases where intermediate analyzes are needed during the sampling process. In this randomization, the method of equal blocks (8 blocks of 4) is used in which in each block, half of the intervention subjects and half are considered as comparisons. And we assigned it to different groups. How and tool to generate random block sequences using the site https://www.sealedenvelope.com/simple-randomiser/v1/lists done. N/A Metabolic syndrome. Intervention 1: Intervention group: training intervention. In the combined training group (resistance-aerobic) an 8-week aerobic program will include three training sessions per week and about one hour per day, which includes running on a treadmill. In this exercise program, subjects with 55% of maximum heart rate for 25 minutes (first 2 weeks), 55 to 65% of maximum heart rate for 35 minutes (second 2 weeks), 65 to 75% of maximum heart rate for 40 minutes Last 4 weeks) practiced. Before starting the exercise, the subjects warmed up for 10 minutes with soft and stretching movements, and at the end of the exercise, they cooled themselves for 10 minutes with stretching movements. Also, the maximum heart rate was obtained through the age-220 formula. Comes and intensity of exercise was adjusted according to the desired percentage of maximum heart rate (Wilmore and Castiel, 1994). Resistance training with bodybuilding machines for 8 weeks and three sessions per week include: horizontal exercises, forearms, leg presses and Swedish swimming. Intervention 2: Control group: Which is not included in any training program. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after unidentified individuals When: Access period starts 6 months after the results are published To whom: It will be available to researchers working in academic and scientific institutions Conditions: The data can be sent to the researcher if the intellectual property rights are protected Where to obtain: Email address How to obtain: Submit a written application and complete the intellectual property form (one week) Comments:
public Homa Naderifar
Mahdiyeh Ave
Hamadan Iran (Islamic Republic of) 6517838678 0098813838063 hnaderifar121@gmail.com Hamedan University of Medical Sciences scientific Homa Naderifar
Mahdiyeh Ave
Hamadan Iran (Islamic Republic of) 6517838678 0098813838063 hnaderifar121@gmail.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Men with metabolic syndrome Age range between 45-65 years 45 years 65 years Male Inability and inability to perform physical activity E88.81 Metabolic syndrome Rehabilitation Other Intervention group: training intervention. In the combined training group (resistance-aerobic) an 8-week aerobic program will include three training sessions per week and about one hour per day, which includes running on a treadmill. In this exercise program, subjects with 55% of maximum heart rate for 25 minutes (first 2 weeks), 55 to 65% of maximum heart rate for 35 minutes (second 2 weeks), 65 to 75% of maximum heart rate for 40 minutes Last 4 weeks) practiced. Before starting the exercise, the subjects warmed up for 10 minutes with soft and stretching movements, and at the end of the exercise, they cooled themselves for 10 minutes with stretching movements. Also, the maximum heart rate was obtained through the age-220 formula. Comes and intensity of exercise was adjusted according to the desired percentage of maximum heart rate (Wilmore and Castiel, 1994). Resistance training with bodybuilding machines for 8 weeks and three sessions per week include: horizontal exercises, forearms, leg presses and Swedish swimming. Control group: Which is not included in any training program Percentage of people who have decreased MicroRNA-122 levels. Timepoint: MicroRNA-122 measurement before and after the intervention. Method of measurement: Dedicated kit. Percentage of people whose sirtuin levels have increased. Timepoint: measurement before and after the intervention. Method of measurement: Dedicated kit. Hamedan University of Medical Sciences Approved 2022-05-07 Ethics committee of University of Medical Scieneces Mahdiyeh Ave Hamadan Hamadan Iran (Islamic Republic of)