]>
IRCT20220506054749N1 IRCT 2022-06-08 Yasouj University of Medical Sciences The effect of hydroalcoholic extract of Nasturtium officinale on quality of life in asthmatic patients The effect of hydroalcoholic extract of Nasturtium officinale on quality of life in asthmatic patients 2022-05-22 anticipated 50 Complete https://irct.ir/trial/63551 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we will use the Restricted randomization method of the randomization Random allocation rule method. For this purpose, first determine a total sample size, then randomly assign a set of them to the intervention group and the rest to the control group. 30 balls for the intervention group and 30 balls for the control group are placed in a lottery container and then the balls are randomly removed from the container without replacement and the created sequence is recorded, Blinding description: Capsules are individually packed envelopes and have an identification number. Capsules and envelopes of Nasturtium officinale extract and placebo are offered in exactly the same appearance and packaging, which will blind the participants and the researcher. 3 Asthma. Intervention 1: Intervention group:Watercress was collected from Shahniz (Margon) region of Kohgiluyeh and Boyer-Ahmad provinces in the summer of 1399. After collecting watercress, 100 grams of plant powder is soaked in 500 ml of ethanol and placed at room temperature for 48 hours. The extract is then filtered and the rest is extracted again with solvent after 24 hours and added to the original extract. The solvent is then evaporated at a temperature of 40 ° C by a rotary refrigerator and incubated at a temperature of 37 ° C to dry extract and stored in the refrigerator at a temperature of 4 ° C for further experiments. To the group of hydroalcoholic extract of watercress in the amount of 500 mg twice a day for 4 weeks. Blood samples and all questionnaires (including ACT test, quality of life and sleep disorders) are completed at the beginning and end of the study by research units. Blood samples are taken from the Clot and CBC tubes. To measure the number of blood eosinophils, a CBC test is performed with a Cismax device. The serum sample is also elucidated and stored at minus -70 ° C. IgE levels are then measured. Intervention 2: Control group: Flour and capsules were prepared and placed in 500 mg capsules in jars of the same shape and size as the main medicine and packaged (of course in the university without my presence) and the patient was explained in person that twice a day. Consume for 28 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Reza Abbasi
Shahid Motahari Boulevard
Yasuj Iran (Islamic Republic of) 7591741417 :33346070-074 amirhosseindoustimotlagh@gmail.com Yasouj University of Medical Sciences scientific Dr Abbasi Reza
Shahid Motahari Boulevard
Yasuj Iran (Islamic Republic of) 7591741417 +98 74 3334 6070 amirhosseindoustimotlagh@gmail.com Yasouj University of Medical Sciences Iran (Islamic Republic of) Both sexes age 18-65 years Asthma diagnosis based on the Global Initiative for Asthma (GINA) Asthma symptoms not fully controlled based on ACT (Asthma Control Test) score from 5 to24 No severe asthma exacerbation in the last four weeks Complete conscious satisfaction 18 years 65 years Both smoking history pregnant women taking any preparation containing NOE J45 Asthma Treatment - Drugs Treatment - Drugs Intervention group:Watercress was collected from Shahniz (Margon) region of Kohgiluyeh and Boyer-Ahmad provinces in the summer of 1399. After collecting watercress, 100 grams of plant powder is soaked in 500 ml of ethanol and placed at room temperature for 48 hours. The extract is then filtered and the rest is extracted again with solvent after 24 hours and added to the original extract. The solvent is then evaporated at a temperature of 40 ° C by a rotary refrigerator and incubated at a temperature of 37 ° C to dry extract and stored in the refrigerator at a temperature of 4 ° C for further experiments. To the group of hydroalcoholic extract of watercress in the amount of 500 mg twice a day for 4 weeks. Blood samples and all questionnaires (including ACT test, quality of life and sleep disorders) are completed at the beginning and end of the study by research units. Blood samples are taken from the Clot and CBC tubes. To measure the number of blood eosinophils, a CBC test is performed with a Cismax device. The serum sample is also elucidated and stored at minus -70 ° C. IgE levels are then measured. Control group: Flour and capsules were prepared and placed in 500 mg capsules in jars of the same shape and size as the main medicine and packaged (of course in the university without my presence) and the patient was explained in person that twice a day. Consume for 28 days. Asthema Control Test score. Timepoint: Before intervention - 28 days after intervention. Method of measurement: ACT test questionnaire. Quality of life. Timepoint: Before intervention - 28 days after intervention. Method of measurement: Quality of Life Questionnaire (SF-12). Quality of sleep. Timepoint: Before intervention - 28 days after intervention. Method of measurement: Petersburg Sleep Quality Questionnaire (PSQI). Number of eosinophils. Timepoint: Before intervention - 28 days after intervention. Method of measurement: Cismax device. Immunoglobulin E. Timepoint: Before intervention - 28 days after intervention. Method of measurement: Spectrophotometry. Yasouj University of Medical Sciences Approved 2020-11-24 Ethics Committee of Yasouj University of Medical Sciences Motahari Boulevard Yasuj Kohgilouyeh-va-Boyrahmad Iran (Islamic Republic of)