IRCT20120215009014N427 IRCT 2022-05-18 Hamedan University of Medical Sciences Effect of intravenous infusion of dexmedetomidine with magnesium sulfate on control of bleeding and surgeon satisfaction during tympanoplasty surgery Effect of intravenous infusion of dexmedetomidine with magnesium sulfate on control of bleeding and surgeon satisfaction during tympanoplasty surgery: a double-blind randomized clinical trial 2022-06-05 anticipated 40 Complete https://irct.ir/trial/63546 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly assigned to intervention and control groups using block randomization. For this purpose, we will prepare four sheets of paper, writing on two sheets the name of the intervention 1 and on the other two sheets the name of the intervention 2. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all four sheets are drawn. The four paper sheets will be then placed back into the container, and this action repeated until the sample size is reached, Blinding description: The shape of the medications will be perfectly the same. Therefore, patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. Thus, the trial will be run as double-blind. 3 Perforation of tympanic membrane. Intervention 1: Intervention group 1: Intravenous infusion of dexmedetomidine at a dose of 1 μg/kg within 15 minutes. Intervention 2: Intervention group 2: Intravenous infusion of magnesium sulfate at a dose of 40 mg/kg within 15 minutes. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situation and the results of the study as well as the approval of the financial supporting organization.