]>
IRCT20220412054511N1 IRCT 2022-12-10 Shahid Beheshti University of Medical Sciences Letrozole for IUI Comparison of letrozole administration to stimulate ovulation in IUI cycles by two methods of 20 mg single dose and 5 days 2023-02-04 anticipated 80 Complete https://irct.ir/trial/63471 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization using randomization software, Blinding description: This study is double-blind and the patient and the researcher do not know which group the patient belongs to. 2 Female Infertility. Intervention 1: Intervention group: Women candidates for IUI who will receive a single dose of Letrozole 20 mg tablet. Intervention 2: Control group: Women candidates for IUI who will receive 5 mg of Letrozole tablets daily for 5 days from the third day of the cycle (common approach). Yes - There is a plan to make this available What will be shared: Only part of the data such as information about the main outcome or the like can be shared. When: 6 months after publication To whom: For researchers working in academic and scientific institutions and people working in industry Conditions: The data of this study can be used for meta-analysis. Where to obtain: The applicant for the information must send an email in English containing the name and how to use this data to the executor's email address. helham260@gmail.com How to obtain: The applicant for the information must send an email in English containing the name and how to use this data to the executor's email address. Information will be sent to them within 10 working days of sending the email. Comments:
public Elham Hashemi
Shahid Beheshti University of Medical Sciences, Koodakiar street
Tehran Iran (Islamic Republic of) 1985717443 +98 21 6605 6115 helham260@gmail.com Shahid Beheshti University of Medical Sciences scientific Elham Hashemi
Shahid Beheshti University of Medical Sciences, Koodakiar street
Tehran Iran (Islamic Republic of) 1985717443 +98 21 6605 6115 helham260@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Have a history of at least one year of infertility Absence of underlying disease including abnormal thyroid stimulating hormone prolactin Spermogram within acceptable range for IUI At least one fallopian tube is open. 20 years 40 years Female History of allergy to letrozole and other aromatase inhibitors History of allergy to cabergoline and other ergot derivatives History of pelvic surgery N97 Female infertility Treatment - Drugs Treatment - Drugs Intervention group: Women candidates for IUI who will receive a single dose of Letrozole 20 mg tablet Control group: Women candidates for IUI who will receive 5 mg of Letrozole tablets daily for 5 days from the third day of the cycle (common approach) Ovarian response (the number of follicle with size more than 14 millimeter). Timepoint: The day 9 to 11 of menstruation cycle. Method of measurement: Vaginal ultrasound. Ovarian response (the size of biggest follicle). Timepoint: The day 9 to 11 of menstruation cycle. Method of measurement: Vaginal ultrasound. Endometrial thickness. Timepoint: The day 9 to 11 of menstruation cycle. Method of measurement: Vaginal ultrasound. The number of HMG ampoules required. Timepoint: from day 11 to 13 menstruation cycle. Method of measurement: Medical record. Pregnancy (Positive BHCG test). Timepoint: Two weeks after IUI (intra uterine insemination). Method of measurement: Blood test. Abortion. Timepoint: During 3 months after pregnancy confirmation. Method of measurement: Getting out of pregnancy products (direct observation or ultrasound). Shahid Beheshti University of Medical Sciences Approved 2022-11-05 Ethics Committee of Shahid Beheshti University of Medical Sciences Shahid Beheshti University of Medical Sciences, Koodakiar street, Tehran Tehran Tehran Iran (Islamic Republic of)