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IRCT20220423054624N1 IRCT 2022-05-25 Shahroud University of Medical Sciences Efficacy of Alprazolam on blood pressure control Comparison of the effect of oral captopril in comparison with alprazolam and oral captopril in controlling blood pressure in patients with urgent hypertension. 2022-05-22 anticipated 94 Complete https://irct.ir/trial/63360 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Other, Randomization description: Patients are randomly divided into two groups of 47 using random allocation software. An envelope will be prepared according to the number of samples, the code of each treatment group will be placed in the envelope, and each patient will be assigned an envelope in which the treatment group is written, Blinding description: Participant: The use of captopril tablets with Folic acid tablets in one group and the use of captopril tablets and alprazolam tablets in another group that the patient is not aware of based on the same color, and shape, and through the use of drugs. Statistical Analyzer: The treatment groups will be provided to the statistical analyzer using the code for analysis. 2 Essential (primary) hypertension. Intervention 1: Intervention group: In the intervention group, patients' blood pressure will be taken and recorded before the drug is administered lying down and the standard method using a mercury sphygmomanometer. Patients are then given a 50 mg captopril tablet and a 0.5 mg alprazolam tablet orally. The drug is prescribed only once at the beginning of the study. The patient will be lying on the bed during the study. In order to check the blood pressure of patients, at 30, 60, 90 and 120 minutes after drug administration (4 times in total), patients' blood pressure is taken and recorded with a mercury sphygmomanometer. Due to the fact that the occurrence of drug side effects is one of the consequences, at 30, 60, 90 and 120 minutes after drug administration, the patient is monitored and the occurrence of side effects is evaluated. Intervention 2: Control group: In the control group, patients' blood pressure will be taken and recorded before the drug is prescribed and the standard method will be taken using a mercury sphygmomanometer. Patients are then given a 50 mg captopril tablet with one folic acid tablet orally. The drug is prescribed only once at the beginning of the study. The patient will be lying on the bed during the study. In order to evaluate the blood pressure status of patients in the control group, in 30, 60, 90 and 120 minutes after drug administration (4 times in total), patients' blood pressure is taken and recorded with a mercury sphygmomanometer. Also, at 30, 60, 90 and 120 minutes after drug administration, the patient is monitored and the occurrence of complications is evaluated. Yes - There is a plan to make this available What will be shared: All collected data will be shared after being unidentified and analysed When: By the end of 2023 To whom: For all scholars Conditions: For use in studies Where to obtain: Emergency department of Imam Hossein Hospital in Shahroud. Responsible person is Dr. Mohammad Reza Khorsand. Postal Code 3614773943 Contact number 09126733459 Imam Hassan Hospital in Shahroud. Emergency department How to obtain: dr.mohhamadreza khorsand Email dr_khorsandmd@yahoo.com Comments:
public DR. Mohammadreza khorsand Kemachali
Room 409, Third floor , Medical School, Shahroud University of Medical Science and Health Services, Hafte Tir Square, Shahroud ,Iran
Shahroud Iran (Islamic Republic of) 3614773943 +98 23 3239 5054 dr_khorsandmd@yahoo.com Shahroud University of Medical Sciences scientific Dr.Mohammadreza Khorsand Kemachali
Room 409, Third floor , Medical School, Shahroud University of Medical Science and Health Services, Hafte Tir Square, Shahroud ,Iran
Shahroud Iran (Islamic Republic of) 3614773943 +98 23 3239 5054 dr_khorsandmd@yahoo.com Shahroud University of Medical Sciences Iran (Islamic Republic of) Systolic blood pressure over 180 or Diastolic blood pressure over 110 age between 18-80 years old Ability to understand and sign the conscientious informed consent No previous Allergy to Captopril or Alprazolam 18 years 80 years Both Left Acute Heart Failure Chronic Renal Failure Cardiovascular disease History of stroke History of myocardial infraction Taking other Benzodiazepines in the last week Taking Muscle Relaxant drugs such as Baclofen Taking anti-anxiety drugs from other group such as Buspirone or Zolpidem Pregnant and Lactating women Occurring an emergency situation which indicates prescribing other Antihypertensive drug based on the Doctor's diagnosis Patients who have more than 15 mmHg difference in blood pressure between arms . I10 Essential (primary) hypertension Treatment - Drugs Treatment - Drugs Intervention group: In the intervention group, patients' blood pressure will be taken and recorded before the drug is administered lying down and the standard method using a mercury sphygmomanometer. Patients are then given a 50 mg captopril tablet and a 0.5 mg alprazolam tablet orally. The drug is prescribed only once at the beginning of the study. The patient will be lying on the bed during the study. In order to check the blood pressure of patients, at 30, 60, 90 and 120 minutes after drug administration (4 times in total), patients' blood pressure is taken and recorded with a mercury sphygmomanometer. Due to the fact that the occurrence of drug side effects is one of the consequences, at 30, 60, 90 and 120 minutes after drug administration, the patient is monitored and the occurrence of side effects is evaluated. Control group: In the control group, patients' blood pressure will be taken and recorded before the drug is prescribed and the standard method will be taken using a mercury sphygmomanometer. Patients are then given a 50 mg captopril tablet with one folic acid tablet orally. The drug is prescribed only once at the beginning of the study. The patient will be lying on the bed during the study. In order to evaluate the blood pressure status of patients in the control group, in 30, 60, 90 and 120 minutes after drug administration (4 times in total), patients' blood pressure is taken and recorded with a mercury sphygmomanometer. Also, at 30, 60, 90 and 120 minutes after drug administration, the patient is monitored and the occurrence of complications is evaluated. Systolic and diastolic blood pressure. Timepoint: checking blood pressure at the beginning of the study and then at 30 ,60 , 90 and 120 minutes after the intervention. Method of measurement: using a clinical mercury manometer device for monitoring the blood pressure in a standardized manner in which patient is lying down. Shahroud University of Medical Sciences Approved 2022-04-17 Ethics committee of Shahroud University of Medical Sciences Room 409, third floor , medical school , Shahroud University of Medical sciences and Health Services, Hafte-Tir Square ,Tehran avenue , Shahroud, Semnan, Iran Shahroud Semnan Iran (Islamic Republic of)