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IRCT20180217038763N4 IRCT 2022-04-25 Mashhad University of Medical Sciences Evaluation of the effect of fibrin coagulation solution on improving nasal polyps Effect of fibrin glue autolog on amandation tissues and relapse polyps on sinusoidal patients after (Functional Endoscopic Sinus Surgery) FESS 2022-04-30 anticipated 32 Complete https://irct.ir/trial/63052 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization, a list of patients who met the inclusion criteria is prepared and 32 patients will be selected using a random number table, Blinding description: This study would be performed with the complete consent of the patients while the patient does not know which side of the nose is treating with control solution and which side of the nose is getting intervention solution. 2-3 Sinonazal polyps. Intervention 1: Control group: During this study, after sinus endoscopic surgery and removal of bilateral polyps, the surgical environment on one side of the patient's nose one cc of normal saline solution is poured inside the nose and the open sinuses by syringe under endoscopic vision. Intervention 2: Intervention group: During this study, after endoscopic sinus surgery and removal of bilateral polyps, the surgical environment on the other side of the same patient's nose received one cc of fibrin coagulation solution prepared from the individual's own serum is poured inside the nose and sinuses opened by a syringe under endoscopic vision. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Deciding after completing the project and consult with other partners
public Mehdi Bakhshaee
Ghaem Hospital, Ahmad Abad AVE
Mashhad Iran (Islamic Republic of) 99199-91766 +98 51 3841 3492 bakhshaeem@mums.ac.ir Mashhad University of Medical Sciences scientific Mehdi Bakhshaee
Ghaem Hospital, Ahmad Abad AVE
Mashhad Iran (Islamic Republic of) 91778-99191 +98 51 3841 2081 Mehbakhsh@yahoo.com Mashhad University of Medical Sciences Iran (Islamic Republic of) Bilateral nasal sinus polyp Identical drug treatment in patients Satisfaction to enter the study 18 years no limit Both Presence of enterocanal polyps Unilateral polyp Immunological diseases prone to improper wound healing History of abnormal bleeding or thrombocytopenia History of previous sinus surgery J33 Nasal polyp Placebo Treatment - Other Control group: During this study, after sinus endoscopic surgery and removal of bilateral polyps, the surgical environment on one side of the patient's nose one cc of normal saline solution is poured inside the nose and the open sinuses by syringe under endoscopic vision. Intervention group: During this study, after endoscopic sinus surgery and removal of bilateral polyps, the surgical environment on the other side of the same patient's nose received one cc of fibrin coagulation solution prepared from the individual's own serum is poured inside the nose and sinuses opened by a syringe under endoscopic vision. Improvement of Sinonazal Polyposis Symptoms. Timepoint: One week, one month and three months after surgery. Method of measurement: Lund-kennedy questionnaire. Mashhad University of Medical Sciences Approved 2022-04-09 Ethics committee of Mashhad University of Medical Sciences Central Building of Mashhad University of Medical Sciences (Ghorshi), Daneshgah 16, Daneshgah street Mashhad Razavi Khorasan Iran (Islamic Republic of)