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IRCT20170108031818N2 IRCT 2022-04-20 Gorgan University of Medical Sciences Evaluation of the effects of hydrocortisone on hemodynamic changes in patients under general anesthesia Comparison of the effectiveness of hydrocortisone and placebo (distilled water) on hemodynamic changes in atracurium for intubation in patients with upper limb fractures (candidate for elective surgery) 2022-04-30 anticipated 48 Complete https://irct.ir/trial/63039 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants in the study were assigned to the intervention (B) and control (A) groups by block randomization. Using a dice that has 6 sides, the samples are assigned to their groups. A number is written on each side and each number is assigned to one of the blocks in the table, which has its own special mode. it shows. Group A (hydrocortisone) and B (placebo of distilled water). A complete list of randomized blocks was provided to the lead researcher by the study epidemiologist, Blinding description: Blinding in this study is double-blind. After obtaining the consent of the participants, they are blind to their study groups and the preparation and dilution of the drug, which are similar in appearance (size, shape, volume of the manufacturer) is done by the nurse in charge of the department. Minutes before entering the operating room (in the ward), people in the hydrocortisone group receive 100 mg of hydrocortisone intravenously and bolus with 300 ml of normal saline. The doctor in charge of the plan and the intervener will not know the type of drug group. Anesthesia induction will be performed by the project resident resident who has no role in the study outcome process. 3 Patients for elective surgery for upper limb fractures. Intervention 1: Intervention group: Individuals in the hydrocortisone group receive 100 mg of hydrocortisone intravenously and bolus with 300 ml of normal saline under the supervision of a nurse who is unaware of the drug groups. Intervention 2: Control group: Individuals in the placebo group receive the same amount of distilled water with 300 ml of normal saline under the supervision of a nurse who is unaware of the drug groups. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is "There is no more information."
public Kazem Kazemnejad Tabrizi
Gorgan, 4 km, Sari, Golestan University of Medical Sciences, Gorgan, Iran. Deputy of Research and Technology of Gorgan, Gorgan, Gorgan
Gorgan Iran (Islamic Republic of) 4934174515 +98 17 3223 8363 mehravar10261@yahoo.com Gorgan University of Medical Sciences scientific Kazem Kazemnejad Tabrizi
Gorgan, 4 km, Sari, Golestan University of Medical Sciences, Gorgan, Iran. Deputy of Research and Technology of Gorgan, Gorgan, Gorgan
Gorgan Iran (Islamic Republic of) 4934174515 +98 17 3223 8363 mehravar10261@yahoo.com Gorgan University of Medical Sciences Iran (Islamic Republic of) All patients for elective surgery between the ages of 15-60 with ASA I or II 15 years 60 years Both All patients for elective surgery between the ages of 15-60 with ASA I or II Metabolic and neuromuscular disorders People if they receive strong antibiotics effective on the effects of relaxants, including aminoglycosides 24 hours before surgery Significant liver and kidney disease Known allergies to narcotics and other drugs used during anesthesia if he took the H1 histamine blocker the day before surgery Obesity (if ideal body weight> 30) T10 Fracture of upper limb, level unspecified Treatment - Drugs Treatment - Drugs Intervention group: Individuals in the hydrocortisone group receive 100 mg of hydrocortisone intravenously and bolus with 300 ml of normal saline under the supervision of a nurse who is unaware of the drug groups. Control group: Individuals in the placebo group receive the same amount of distilled water with 300 ml of normal saline under the supervision of a nurse who is unaware of the drug groups. Hemodynamic changes. Timepoint: Hemodynamics will be recorded in the relevant list before the administration of hydrocortisone and 30 minutes after the administration of hydrocortisone or at the entrance to the operating room and 5 minutes after the peak effect of atracurium (before intubation) and after ecstasy. Method of measurement: This monitoring will be performed under the supervision of an anesthesiologist based on patient monitoring instructions, including continuous monitoring of heart rate, arterial oxygen saturation and intermittent and non-invasive measurement of systolic and diastolic blood pressure and bronchospasm by Saadat's monitoring device. Gorgan University of Medical Sciences Approved 2021-11-28 Ethics Committee of Golestan University of Medical Sciences Gorgan, 4 km, Sari, Golestan University of Medical Sciences, Gorgan, Iran. Deputy of Research and Technology of Gorgan, Gorgan, Gorgan Gorgan Golestan Iran (Islamic Republic of)