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IRCT20220201053906N1 IRCT 2022-06-05 Shahroud University of Medical Sciences Evaluation of the effect of Ketamine by nebulizer in reducing pain caused by renal colic. Comparison of the analgesic effect of nebulized Ketamine versus intravenous Ketorolac in reducing pain of patients with renal colic who refer to emergency department 2022-05-22 anticipated 108 Complete https://irct.ir/trial/62884 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patient will be randomly divided into 2 groups of 54, using random allocation software. Treatments will start randomly from the first patient who has inclusion criteria. First, the numbers 1 to 108 will be written on 108 envelopes. There is a sheet containing the code of each patient's treatment  in each envelope, which is defined by the random allocation software that determines the treatment of each patient. Every patient with inclusion criteria will be allocated an envelope, Blinding description: This study is double-blinded. To blind the patient, the  pain assessor and statistical analyzer a code will be allocated for each patient. Just emergency medicine specialist and nurse know the meaning of the cods. To make the patient blind, Ketorolac syringe and a placebo nebulizer or Ketamine nebulizer and a placebo syringe will be prepared. After collecting the data, the data will be entered into SPSS using random allocation software codes and will be provided to the statistical analyzer for analysis. Pain is a mental variable, therefore, making the pain assessor blind is important. So, the pain assessor who assesses the intensity of pain doesn't know the codes of each treatment, just knows the treatment code of each patient. 3 Renal colic. Intervention 1: Intervention group: The nurse nebulizes 0.5 mg/kg Ketamine and injects 1 cc / kg normal saline For the patient who is a member of the intervention group. Intervention 2: Control group: The nurse injects 1mg/kg of Ketorolac and 0.5 cc / kg of distilled water is nebulizes for the patient in the control group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more dada
public Yasaman Safari
Narges dirmitory, Shahid Fakori Blvd.
Shahrood Iran (Islamic Republic of) 3616911151 0098 21 2231020 asemon.violet@gmail.com Shahroud University of Medical Sciences scientific Hosein Amiri largani
Emergency department, Imam Hosein hospital, Imam Hosein Sq.
Shahrood Iran (Islamic Republic of) 3616951835 +98 23 3234 2000 amirilargani@shmu.ac.ir Shahroud University of Medical Sciences Iran (Islamic Republic of) Patients 20-70 years old With acute pain in one side flank Has informed consent 20 years 70 years Both Unstable patients ( SBP<90, HR>100 or HR<60, fever) Pregnant or Suspicion of pregnancy Single kidney Hasn't informed consent or unable to have informed consent Want to discharge before ending the study(2 hours after starting the study) History of addiction History of take analgesic at least 6 hours Symptom or sign of acute abdominal (tenderness, guarding, rebound) Need Rescue dose before ending of the study N23 Unspecified renal colic Treatment - Drugs Treatment - Drugs Intervention group: The nurse nebulizes 0.5 mg/kg Ketamine and injects 1 cc / kg normal saline For the patient who is a member of the intervention group. Control group: The nurse injects 1mg/kg of Ketorolac and 0.5 cc / kg of distilled water is nebulizes for the patient in the control group. Score of renal colic pain in NRS. Timepoint: Before starting the study, 5, 15, 30 and 60 minutes after starting the study. Method of measurement: Numeric rating scale (NRS). Patient satisfaction with pain control. Timepoint: 2 hours after the start of the study. Method of measurement: Asking verbal. Side effects of the treatments. Timepoint: Before starting the study, 5, 15, 30, 60 minutes after starting the study and if the patient has been in the hospital for more than 2 hours; At the time of discharge of the patient. Method of measurement: Medical history and physical examination. Duration of the patient's presence in the emergency department. Timepoint: At the time of discharge of the patient. Method of measurement: Clock. Shahroud University of Medical Sciences Approved 2022-01-28 Ethics Committee of Shahroud University of Medical Sciences No. 2, Sixth Alley, Shahid Rajaee Ave., Shahroud Semnan Iran (Islamic Republic of)