IRCT20141001019359N12 IRCT 2022-04-08 Bojnourd University of Medical Sciences Comparison of the effect of Intrathecal addition of Dexmedetomidine and Sufentanil to Bupivacaine in Patients Undergoing Knee Prosthesis Comparison of the effect of Intrathecal addition of Dexmedetomidine and Sufentanil to Bupivacaine in Patients Undergoing Knee Prosthesis under Spinal Anesthesia: a Double-blind Randomized Clinical Trial 2022-05-22 anticipated 90 Complete https://irct.ir/trial/62790 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Sampling in this study will be that first in order to enter the study patients will be in the form of non-random sampling of the type "available" and then divide them into three intervention groups by randomly assigned blocking using a web-based system. Random blocking at www.randomization.com will be done in 15 blocks of 6. So that in each block, there are 2 people in the first group (A), two people in the second group (B) and two people in the third group (C). After a random sequence was identified in all blocks, cards were written by writing C, B, and A to indicate which group each patient was assigned to, and by someone other than the research team from 1 to 90 in all blocks, respectively. They are numbered and these cards are placed in sealed non-transparent envelopes, respectively. Then, in order to hide the random allocation, when the patient visits, the opaque sealed envelope will be opened and then one by one, it will be determined for each sample of the relevant group, Blinding description: None of the participants in the study will be aware of the randomization list, and in order to conceal the randomization process, the groups will be placed in closed envelopes in the reception area and will be assigned to the eligible individuals who enter the study. Participants also referred to the type of intervention (drugs in the syringe for injection into the intrathecal space) because the syringes had already been diluted to the same volume; And the position of the patients will not be known during the spinal anesthesia technique. Therefore, the study is double-blind so that patients and the outcome assessment specialist are unaware of the status of the three groups assigned to the study. 3 pain. Intervention 1: Intervention group 1: In this group of patients to perform spinal anesthesia, anesthesiologist in combination with the main anesthetic drug (bupivacaine); 10 micrograms of dexmedetomidine will be injected into the intrathecal space. Intervention 2: Intervention group 2: In this group of patients to perform spinal anesthesia, anesthesiologist in combination with the main anesthetic drug (bupivacaine); ٥ micrograms of sufentanil will be injected into the intrathecal space. Intervention 3: Control group:In this group of patients, for spinal anesthesia, the anesthesiologist will inject only the main anesthetic (bupivacaine) into the intrathecal space. No - There is not a plan to make this available Justification or reason for not sharing IPD is اطلاعات بیشتری وجود ندارد.