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IRCT201102065775N1 IRCT 2011-04-10 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity: a pilot prospective case-control study Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity: a pilot prospective case-control study 2009-02-01 anticipated 21 Complete https://irct.ir/trial/6268 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Acute renal failure. Intervention 1: pure oxygen 60% via non-rebreathing reservoir mask for 2 hours at 48, 24 and 6 hours before intravenous administration of cisplatin. Intervention 2: Docetaxel (trade name Taxotere) was given 75 mg/m2 intravenous on day 1. Intervention 3: 2-3 Liter of normal saline intravenous on the day of cisplatin administration during 4-6 hours. Intervention 4: cisplatin 50 mg/m2 at the second day intravenous. Intervention 5: 5-FU 350 mg/m2 intravenous for five days after injection of cisplatin.
public Behzad Einollahi
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences
Tehran Iran (Islamic Republic of) +98 21 8126 2073 einollahi@ijnu.ir Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences scientific Behzad Einollahi
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences
Tehran Iran (Islamic Republic of) +98 21 8126 2073 einollahi@ijnu.ir Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: the patients who treated with cisplatin due to cancer Exclusion criteria: The patients who had chronic obstructive lung disease, pneumothorax, upper respiratory infection, fever, viral infection, history of seizure, optic nerve inflammation, history of ear surgery and history of heavy cigarette smoking were excluded from this study. None of female patients was pregnant. no limit no limit Both N17 Acute renal failure Prevention Prevention Prevention Treatment - Drugs Treatment - Drugs pure oxygen 60% via non-rebreathing reservoir mask for 2 hours at 48, 24 and 6 hours before intravenous administration of cisplatin. Docetaxel (trade name Taxotere) was given 75 mg/m2 intravenous on day 1 2-3 Liter of normal saline intravenous on the day of cisplatin administration during 4-6 hours cisplatin 50 mg/m2 at the second day intravenous 5-FU 350 mg/m2 intravenous for five days after injection of cisplatin. Serum Creatinine. Timepoint: 0, 6,24,48. Method of measurement: Serum creatinine measurment previous day and 6, 24, 48 houre after Hyperoxia preconditioning. EGFR decrementation. Timepoint: -1, 0, 2, 5 days after threatment. Method of measurement: plasma creatinine for GFR estimation in all patients in-1, 0, 2 and 5 days after cisplatin exposures. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences Approved 2008-06-02 Ethics committee of Baqiyatallah University Baqiyatallah Hospital Tehran Iran (Islamic Republic of)