IRCT20210123050123N1 IRCT 2022-03-30 Rasht University of Medical Sciences Effect of vitamin C on head truama ; The effect of high dose of vitamin C on brain acute phase biomarker in patients with diffuse axonal brain injury . 2022-04-09 anticipated 90 Complete https://irct.ir/trial/62606 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Identified patients are randomly divided into two groups of drugs and placebo based on a random block, and the method of selecting patients is that each patient is randomly assigned to the hospital by an emergency physician who is familiar with the type of study but not familiar with assignment of patients . They are divided into two groups, A and B, based on RANDOM software, Blinding description: The attending physician will inject the type of drug or placebo based on the choice of A and B at the time of the study and the drug will be written as codes A and B. The injector, patient and donor have no information about its type. Patients' legal guardians will also be given the necessary explanations regarding the objectives of the study and the method of conducting the study, and they will be informed that they may receive one of the types of drugs A or B and will obtain their informed consent. 3 Description of patients with diffuse brain injury. Intervention 1: Intervention group: Intervention group: Receiving vitamin C in a dose of 10 g / 100 ml daily as a continuous infusion (4.166 ml / h) for 7 days. Intervention 2: Control group: ormal saline (100 ml with the same color and shape as the drug) as a continuous infusion (4.166 ml / h) daily for 7 days. Yes - There is a plan to make this available What will be shared: Published in prestigious journals When: 2 years To whom: Professors and students Conditions: Publication of a scientific article Where to obtain: The person in charge of the project How to obtain: Processing and receiving Comments: