IRCT20220221054087N1 IRCT 2022-03-09 Kashan University of Medical Sciences Investigate the effect of Crocin in Multiple Sclerosis patients Investigate the effect of Crocin on Cognitive impairment, mental health,Oxidative Stress and inflammatory factors in Multiple Sclerosis patients 2022-04-08 anticipated 50 Complete https://irct.ir/trial/62257 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be performed with simple method and random numbers generated by computer software (Stat Trek software) which choose the random numbers. Then, we consider the specific numbers for both groups for example: the even numbers are for intervention group and the odd numbers are for the placebo group, Blinding description: Randomization and allocation will be concealed from the researchers and participants until the final analyses are completed. Another person at the clinic, who is not involved in the trial and not aware of random sequences, will be assigned the participants to the numbered bottles of supplements. Supplements and placebos are only the code is written on the packages. Patients and researcher do not know the type of intervention and after analyzing the data, packet codes are decoded. 2 Multiple Sclerosis. Intervention 1: Intervention group: In this group of patients (n=25) will be requested to take two crocin tablets daily for 8 weeks (each tablet contain 15 mg crocin). The crocin tablets will be produced in the pharmacy faculty of Mashhad University of Medical Sciences from saffron. Intervention 2: Control group: In this group of patients (n=25) will be requested to take two placebo tablets daily for 8 weeks. The placebo tablets (Contain Avicel) will be produced in the pharmacy faculty of Mashhad University of Medical Sciences. No - There is not a plan to make this available Justification or reason for not sharing IPD is Dr. Bahador Rezapoor Kafteroodi is committed to presenting all the achievements of the project in accordance with the framework of the National Institute for Medical Research Development in the Islamic Republic of Iran.