IRCT20220226054132N1 IRCT 2022-03-06 Rasht University of Medical Sciences A Comparison of the effect of lidocaine, articaine and mepivacaine on pulpal anesthesia in maxillary molars with irreversible pulpitis A Comparison of the effect of lidocaine, articaine and mepivacaine on pulpal anesthesia in maxillary molars with irreversible pulpitis (double-blind randomized trial) 2022-04-02 anticipated 114 Complete https://irct.ir/trial/62222 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: For randomization, the block randomization method with 4 permutation blocks will be used. For this reason, considering that the study is double-blind and only analysts are aware of the study groups, considering the blind therapies A, B and C, the order of assigning treatment to individuals based on the time of their study will be as follows: (The complete randomization file is available as an Excel file. The randomization was done with SAS software version 9): Seed: 117257145755086 Block sizes: 6 Actual list length: 114 block identifier, block size, sequence within block, treatment • 1, 6, 1, Group C • 1, 6, 2, Group B • 1, 6, 3, Group C • 1, 6, 4, Group A • 1, 6, 5, Group A • 1, 6, 6, Group B • 2, 6, 1, Group B • 2, 6, 2, Group C, Blinding description: All patients are divided into three experimental groups by block randomized randomization. Patients are classified into four subgroups based on sex and tooth type (maxillary first or second molars). Patients in each subgroup are then randomly assigned to lidocaine, articaine, and mepivacaine groups using six blocks. Equal number of lidocaine and articaine and mepi-cocaine cartridges are prepared and given a code. To hide random allocation, a code-aware nurse randomly provides cartridges to clinicians based on groups (lidocaine, articaine, and mepivacaine). There is a code for each packed cartridge. One clinician fills out a questionnaire. And another clinician does the injections. All injections are performed by a clinician. This is a double-blind study, meaning that the clinician performing the injections, the patient, the person evaluating the outcome, and the statistician are not aware of the type of anesthetic. 2-3 Irreversible pulpitis. The first intervention group: lidocaine receiving group - the second intervention group: articaine receiving group - the third intervention group: mipivacaine receiving group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information