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IRCT20210901052358N2 IRCT 2022-03-08 Shahid Beheshti University of Medical Sciences Evaluation of the efficacy of Hydroxyurea administration on blood oxygen saturation of COVID-19 patients Evaluation of the efficacy of Hydroxyurea administration on blood oxygen saturation of hospitalized patients with severe COVID-19 2022-03-21 anticipated 10 Complete https://irct.ir/trial/62110 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A COVID-19. Intervention group: This study is performed on only one group of patients who all receive hydroxyurea tablets (500 mg three times a day) in addition to the usual COVID-19 treatments according to the national guideline. Usual treatments include serum therapy, vitamins, supplemental oxygen, and remdesivir (200 mg intravenously for first day and 100 mg daily intravenously for the next 4 days).. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Amirreza Keyvanfar
No. 2, 2nd east Ave., Imam Reza St., Takhti St., Ashrafi esfahani Highway.
Tehran Iran (Islamic Republic of) 1477695469 +98 21 4483 1899 amirrezakeyvanfar@yahoo.com Shahid Beheshti University of Medical Sciences scientific Amirreza Keyvanfar
No. 2, 2nd east Ave., Imam Reza St., Takhti St., Ashrafi esfahani Highway.
Tehran Iran (Islamic Republic of) 1477695469 +98 21 4483 1899 amirrezakeyvanfar@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Laboratory confirmation of Coronavirus disease-19 (COVID-19) virus by reverse transcription- polymerase chain reaction (RT-PCR) Oxygen saturation less than 90% Respiratory rate more than 24 per minute More than 50% involvement of the lung parenchyma on CT scan 18 years no limit Both White blood cell count less than 2500 million cells per microliter Absolute neutrophil count less than 1000 million cells per microliter Platelet count less than 80,000 cells per microliter More than 50% increase in creatinine compared to the amounts of admission time Pregnancy Active hepatitis B or C infections U07.1 COVID-19, virus identified Treatment - Drugs Intervention group: This study is performed on only one group of patients who all receive hydroxyurea tablets (500 mg three times a day) in addition to the usual COVID-19 treatments according to the national guideline. Usual treatments include serum therapy, vitamins, supplemental oxygen, and remdesivir (200 mg intravenously for first day and 100 mg daily intravenously for the next 4 days). Peripheral blood oxygen saturation. Timepoint: Every other day after starting treatment (up to a week). Method of measurement: Pulseoxymeter. Hemoglobin F levels. Timepoint: Every other day after starting treatment (up to a week). Method of measurement: Hemoglobin electrophoresis. Blood cell count. Timepoint: Every other day after starting treatment (up to a week). Method of measurement: Laboratory report. Shahid Beheshti University of Medical Sciences Approved 2021-06-13 Organizational Committee of Ethics in Biomedical Research, Shahid Beheshti University of Medical Sci Shahid Beheshti University of medical sciences, Arabi St., Daneshjoo Blvd,. Yaman St,. Chamran highway. Tehran Tehran Iran (Islamic Republic of)