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IRCT20111212008384N8 IRCT 2022-02-24 Vice Chancellor for Research, Mashhad University of Medical Science Comparison of ketamine and methadone in pain control of addicts after surgery Comparison of analgesic effect of low dose of ketamine vs. methadone on opioid abusers undergoing surgery 2021-12-22 anticipated 220 Complete https://irct.ir/trial/62044 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization is used. In this method, 55 blocks of 4 are selected through the relevant sites. Then 110 letters A are prepared and 110 letters B are prepared. Opaque envelopes are also used for concealment. 220 envelopes are prepared and the letters A and B are placed in the extracted blocks, respectively. The envelopes are sealed and given to the patient's recipient. Each patient is given an envelope (in order) at the time of referral, which the patient will provide to the doctor. The letter A represents the methadone group and the letter B represents the ketamine group, Blinding description: In this study, the person evaluating the amount of pain will be unaware of the allocating people in the two study groups. 3 pain. Intervention 1: Intervention group: Ketamine will be administered in the ICU 0.5 mg per kg every 6 hours intravenously. Intervention 2: Control group: In the control group, 5 mg of methadone is administered every 8 hours. Yes - There is a plan to make this available What will be shared: Data can potentially be shared after people are not identified When: The access period starts 6 months after the results are published To whom: It will be available to researchers working in academic and scientific institutions Conditions: After correspondence with the scientific person in charge of the project and after the publication of the article, by preserving the intellectual rights of the authors, it is possible to access the data and perform analysis on the information. Where to obtain: To request data, you can correspond by email to the person in charge of the scientific plan How to obtain: To request data, you can correspond by email to the person in charge of the scientific plan Comments:
public Dr. Arash Peivandi Yazdi
Surgical Oncology Research Center, Imam Reza Hospital,Faculty of Medicine, Mashhad University of Medical Sciences
Mashhad Iran (Islamic Republic of) ٩١٣٧٩١٣٣١۶ +98 51 1802 2677 PeivandiA@mums.ac.ir Mashhad University of Medical Sciences scientific Dr. Arash Peivandi Yazdi
Surgical Oncology Research Center, Imam Reza Hospital,Faculty of Medicine, Mashhad University of Medical Sciences
Mashhad Iran (Islamic Republic of) ٩١٣٧٩١٣٣١۶ +98 51 1802 2677 PeivandiA@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Addicted patients who are candidates for GA abdominal surgery require special postoperative care Age between 20 to 65 years History of daily drug use for the past 6 months 20 years 65 years Both Known drug allergy to ketamine or methadone History of hypertension or PAP History of severe systemic disease History of psychiatric illness high ICP History of alcohol and psychotropic substances Prohibition of intramuscular injection Pregnancy Treatment - Drugs Treatment - Drugs Intervention group: Ketamine will be administered in the ICU 0.5 mg per kg every 6 hours intravenously Control group: In the control group, 5 mg of methadone is administered every 8 hours Pain. Timepoint: At the beginning, every 3 hours, after 24 hours. Method of measurement: Using the Verbal Scoring System (NRS) we will use zero as the minimum and 10 as the maximum number of pain. Vice Chancellor for Research, Mashhad University of Medical Science Approved 2021-01-19 Ethics committee of Mashhad University of Medical Sciences Department of anesthesiology, Imam Reza hospital, Shariati Square Mashhad Razavi Khorasan Iran (Islamic Republic of)