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IRCT20101201005287N3 IRCT 2022-02-22 Tabriz University of Medical Sciences Cranberry fruit in COVID-19 Comparison of the effectiveness of cranberry fruit and placebo in the treatment of symptoms of Covid-19 patients 2021-12-09 anticipated 120 Complete https://irct.ir/trial/61945 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: From the patients who volunteered to participate in the study, 120 people will be selected by simple random sampling. Randomization method: block Randomization unit: individual Random layers: In each block, people will be matched based on age and gender. Random Allocation tool: Random Allocation software How to build a random sequence: Using Random Allocation software Concealment: A random sequence created in a safe place and performed by an independent, non-independent person during the study, Blinding description: This study is a double-blind study that evaluates the consequences in this study and patients participating in the study will be unaware of the type of supplement received. Supplements will be provided to patients by another person who has no role in completing the questionnaire. Patients will also be informed of the existence of two types of supplements (cranberry fruit capsules and placebo) when obtaining consent, but will be unaware of which study groups they will be placed in. The capsules are exactly the same in shape, color and size and will smell the same due to their proximity for several days. 3 COVID-19, virus identified. Intervention 1: Intervention group: For 14 days, patients received the cranberry capsule (500 g) prepared in Tabriz School of Pharmacy, while receiving it from the researcher while visiting Imam Reza Hospital, and consumed one glass daily with a glass of water. Intervention 2: Control group: For 14 days, patients received a starch capsule (500 g) prepared in Tabriz School of Pharmacy, while visiting the Imam Reza Hospital from a researcher, consuming one daily with a glass of water. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Akbar Sharifi
Bronchoscopy ward, Emam Reza hospital, Golgasht street
Tabriz Iran (Islamic Republic of) 1566614766 +98 41 1337 5449 asharifi@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Akbar Sharifi
Bronchoscopy ward, Emam Reza hospital, Golgasht street
Tabriz Iran (Islamic Republic of) 1566614766 +98 41 1337 5449 asharifi@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Confirmation of Covid-19 by PCR test Satisfaction to participate in the study no limit no limit Both Having an underlying disease Pregnant patients Stop taking the drug U07.1 COVID-19, virus identified Treatment - Drugs Placebo Intervention group: For 14 days, patients received the cranberry capsule (500 g) prepared in Tabriz School of Pharmacy, while receiving it from the researcher while visiting Imam Reza Hospital, and consumed one glass daily with a glass of water. Control group: For 14 days, patients received a starch capsule (500 g) prepared in Tabriz School of Pharmacy, while visiting the Imam Reza Hospital from a researcher, consuming one daily with a glass of water. Interleukin-6 blood levels of patients before and after taking the drug. Timepoint: Before starting the drug and 14 days after taking the drug. Method of measurement: Blood sample analysis for IL-6 by ELISA in the laboratory. Serum TNF-α levels in patients' plasma. Timepoint: At the beginning of the study (before the intervention) and 14 days after starting the drug. Method of measurement: Blood sample analysis for TNF-α by ELISA in the laboratory. Tabriz University of Medical Sciences Approved 2021-12-09 Ethics committee of Tabriz University of Medical Sciences Emam Reza hospital, Golgasht Ave Tabriz East Azarbaijan Iran (Islamic Republic of)