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IRCT20111212008384N7 IRCT 2022-02-22 Mashhad University of Medical Sciences Comparison of the effect of hypertonic and normal saline on the success of resuscitation in patients with septic shock Comparison of the effect of hypertonic and normal saline on the success of resuscitation in patients with septic shock during the first three hours of treatment 2022-02-20 anticipated 52 Complete https://irct.ir/trial/61931 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: The diameter of the optic nerve in both groups is measured and recorded by ultrasound before treatment and after 3 hours, Randomization description: After obtaining informed consent from the patient's first-degree relatives, patients are randomly divided into control and intervention groups (using sealed envelopes). For randomization based on a random sequence created from www.randomization.com and the order in which patients enter the study, they will be included in the control or intervention group, Blinding description: The subjects and the treating physician will be unaware of the intervention and control groups. 3 Septic shock. Intervention 1: In the intervention group, 5% hypertonic saline is prescribed at the rate of 5 cc per kg of body weight at the beginning of septic shock treatment. Intervention 2: In the control group, conventional resuscitation is performed (initial targeted treatment with 30 cc of isotonic saline per kilogram of body weight during the first 3 hours of septic shock). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Arash Peyvandi Yazdi
Ibn Sina St., Imam Reza Hospital, Building 610, Surgical ICU
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3854 3031 peivandia@mums.ac.ir Mashhad University of Medical Sciences scientific Arash Peyvandi Yazdi
Ibn Sina St., Imam Reza Hospital, Building 610, Surgical ICU
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3854 3031 peivandia@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Patients with septic shock, Age between 80-18 years 18 years 80 years Both Patient dissatisfaction, Patients with incurable disseminated malignancy, Patients with hypernatremia, Patients receiving colloidal solutions such as albumin, etc. Any volume-limiting restrictions such as irreversible heart failure R57.2 R57.2 Treatment - Drugs Treatment - Drugs In the intervention group, 5% hypertonic saline is prescribed at the rate of 5 cc per kg of body weight at the beginning of septic shock treatment. In the control group, conventional resuscitation is performed (initial targeted treatment with 30 cc of isotonic saline per kilogram of body weight during the first 3 hours of septic shock). Hemodynamic parameters (heart rate, mean arterial pressure, systolic blood pressure, diastolic blood pressure, central venous pressure). Timepoint: At the beginning of the patient's study and in the first, second and third hours of the intervention. Method of measurement: Hemodynamic parameters by monitoring device andCentral venous pressure rulers are measured. 1- Gasometric parameters 2- Optical nerve diameter. Timepoint: At the beginning of the patient's study and in the first, second and third hours of the intervention (optic nerve diameter at the beginning and the third hour of the intervention), they are measured, recorded and compared. Method of measurement: Gasometer and sonography device. Mashhad University of Medical Sciences Approved 2021-12-14 Ethics committee of Mashhad University of Medical Sciences Ibn Sina St., Imam Reza Hospital, Building 610, Surgical ICU mashhad Razavi Khorasan Iran (Islamic Republic of)