IRCT20191218045795N5 IRCT 2022-03-17 Sanandaj University of Medical Sciences The effect of mirtazapine on neuroleptic-induced acute akathisia The effect of mirtazapine on neuroleptic-induced acute akathisia 2022-02-07 anticipated 50 Complete https://irct.ir/trial/61926 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: 4 - block allocationrandom Patients are placed in two groups A and B by the assistant using the randomized block method. For this randomization, pre-prepared cans and medicines are made by the pharmacist and based on the patients in the order provided by the statistical consultant. The patient and the outcome researcher are unaware of which of the two groups is receiving the medication or placebo. Random allocation method: Individuals are assigned to the intervention and control groups using the method of forming 4 random blocks as follows. AABB, ABAB, BBAA, BABA A: Intervention Group B: Control Group Up to 48 people are randomized using the formation of 4 random blocks and random selection from the sequence of these blocks. For the remaining two people, each of them will be placed in one of the intervention and control groups using the lottery method, Blinding description: placebo was made of inert substances designed to have no effect. In this study, except for the pharmacist who prepared the medication and placebo, all the other people including psychiatrists, patients, and researchers were blind to the study groups. 3 آکاتیزیا. Intervention 1: Intervention group: The intervention in this study is mirtazapine. First, mirtazapine powder (manufactured by Tekaje-Iran under the brand name Rpizapine) which is prepared by a pharmacologist, is poured into empty capsules in the amount of 15 mg with empty scales. Mirtazapine is easily poured from The gastrointestinal tract is absorbed and reaches the maximum blood level within two hours. Extensively metabolized in the liver, the most important biotransformation pathways of this drug are demethylation and oxidation. The capsules are then given to the patients in the intervention group by a trained nurse for 7 days at 9 pm. Intervention 2: Control group: Placebo is prepared based on the color of the requested powder (including flour, starch and pigment) and in the amount of 15 mg in the same capsules where the drug was poured, and it is completely the same shape, color and smell of mirtazapine. It also has no effect on acacia. Yes - There is a plan to make this available What will be shared: participant individual data When: 6 months after publication To whom: people working in academic institutions Conditions: researcher working on academic institution Where to obtain: nshamsalizadeh@yahoo.com How to obtain: 2 month Comments: