IRCT20220206053955N1 IRCT 2022-03-15 Iran University of Medical Sciences Comparing the Effect of preoperative skin preparation with povidone-iodine and chlorhexidine-gluconate on the surgical site infection Comparing the Effect of preoperative skin preparation with povidone-iodine and chlorhexidine-gluconate on the surgical site infection 2021-04-21 anticipated 70 Complete https://irct.ir/trial/61923 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Simple randomization was done with random number table made by computer. According to the random number table, each patient was given a specific number which only the researcher was aware of it, Blinding description: Participants and data analyzers were blinded to which antiseptic we used in study. however, surgeon and surgical team as well as the researcher knew about which antiseptics were used for patients because of their color. N/A Surgical site infection, Antiseptic, Povidone Iodine, Chlorhexidine Gluconate, Skin Preparation. Intervention 1: Control group: After the induction of general anesthesia, the first step of surgical site skin preparation (skin prep) was done with povidone iodine 7.5% solution for about 3-5 minutes by the researcher with standard rotational method. then the remains of antiseptic solution was cleaned with sterile towel. The second step of skin prep was done with povidone iodine 10% solution and the procedure was like the first step. Intervention 2: Intervention group: After the induction of general anesthesia, the first step of surgical site skin preparation (skin prep) was done with chlorhexidine gluconate 2% / isopropyl alcohol 70% solution for about 3-5 minutes by the researcher with standard rotational method. then the remains of antiseptic solution was cleaned with sterile towel. The second step of skin prep was done with chlorhexidine gluconate 2% / isopropyl alcohol 70% solution and the procedure was like the first step. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.