IRCT20210719051943N2 IRCT 2022-03-06 Ghoum University of Medical Sciences Eradicate Helicobacter pylori infection Evaluating the Effectiveness of Treatment by piloshot Probiotic and Standard Quadruple Regimen in Patients with Helicobacter Pylori 2022-05-22 anticipated 200 Complete https://irct.ir/trial/61751 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization method will be used and the block size is 4. Considering our sample size equal 200, we used 50 blocks. The selection among 6 possible blocks will be conducted based on simple random sampling. 6 possible blocks are including AABB, ABAB, BBAA, BABA, ABBA, BAAB, Blinding description: After completing the entry criteria and obtaining informed consent, patients are referred to a caregiver to receive medication.At this stage, the caregiver accidentally gives the patient drug packages that include groups A and B.The patient, the researcher, and the caregiver have no say in the selection.After completing the treatment process by patients and follow-up to eradicate, the examination begins as to which patient has taken which drug.Thus, none of the groups of researchers, participants and caregivers are involved in the choice of treatment. 3 Helicobacter Pylori. Intervention 1: Control group: Patients in the control group will be treated with the four-drug regimen of two capsules of amoxicillin 500 every 12 hours,one clarithromycin 500 capsules every 12 hours,one pantoprazole 40 every 12 hours,two bismuth tablets every 12 hours with 2 placebo of piloshot daily(contains lactose mesh 200,ac-di-sol,talc,colloidal silicon dioxide and magnesium stearate). Intervention 2: Intervention group: :Patients in the intervention group under the helicobacter pylori eradication will be treated with four-drug regimen, including two capsules of amoxicillin 500 every 12 hours plus one clarithromycin 500 capsules every 12 hours and two bismuth tablets every 12 hours plus one pantoprazole 40 every 12 hours will be accompanied by 2 capsules of Pilochet (containing Lactobacillus ruteri, casei ,Acidophilus and Bifidobacterium) daily. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The results of the study should be reviewed.