IRCT20100102002954N26 IRCT 2022-02-28 Shahroud University of Medical Sciences Comparison of the effect of Adalimumab and Methotrexate in the treatment of psoriasis Comparison of the efficacy of Adalimumab and Methotrexate in cases of moderate to sever of psoriasis, a double-blind clinical trial 2022-03-01 anticipated 92 Complete https://irct.ir/trial/61717 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were allocated to intervention and control groups according to random allocation table that illustrated by a statistician. Randomization was done using permuted block randomization method (Block size was 4) using blocked random allocation syntax in SPSS software. For calculation sample size was 92 and number of blocks was 23. Allocation concealment was done using closed opaque envelope, Blinding description: In this study outcome evaluator and data analyzer are blinded. The division of patients into two groups intervention and control, review and record treatment results is done by a qualified nurse who has no knowledge of the actions performed in the two groups. Data analysis will also be performed by a project epidemiologist who has no knowledge of patient grouping. 2-3 Moderate to sever of psoriasis. Intervention 1: Intervention group: For patients in the intervention group, in addition to routine treatment (including the use of glycerin topical lotion 10% and 25 mg hydroxyzine tablets three times a day), 80 mg of Adalimumab ampoule subcutaneously to begin and then 40 mg a week later as subcutaneously and then 40 mg subcutaneously every two weeks for 16 weeks. Intervention 2: Control group: For patients in the control group, in addition to routine treatment (including topical 10% glycerin lotion and 25 mg hydroxyzine tablets three times daily), 20 mg of Methotrexate ampoule intramuscularly to start and then 10 mg intramuscularly one week later and then 10 mg intramuscularly will be administered every two weeks for 16 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After completing the research and summarizing the results, it will be decided.