IRCT20180416039326N20 IRCT 2022-02-26 Esfahan University of Medical Sciences The effect of cardiovascular response to sedation with dexmedetomidine, midazolam and atomidite in cataract surgery Comparison of cardiovascular response to sedation with dexmedetomidine, midazolam and etomidatein phacoemulsification under local anesthesia 2022-02-20 anticipated 90 Complete https://irct.ir/trial/61702 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The division of patients into two groups is based on a random number table, Blinding description: The study is double blinded.Patient and researcher are unaware of patient groups and type of medication.The medications are prepared by an anesthetist who is unaware of the grouping of patients and is worn by an aluminum foil and encoded by an anesthetist.Demographic information; Sedation level. The quality of pain relief and hemodynamic variables and complications are collected by a patient who is not aware of the type of drug and patient grouping. 3 Cataract surgery. Intervention 1: Intervention group: In dexmedetomidine group (D), patients will receive 1 /g / kg of dexmedetomidine in 20 ml of normal saline for 10 minutes followed by infusion of dexmedetomidine at 0.5 /g / kg / h. Intervention 2: Intervention group: In the midazolam group (M) patients will receive 0.05 mg / kg of slow intravenous midazolam. Intervention 3: Intervention group: In the atomidite group (E) they will receive 0.2mg / kg. In all three groups, 1.5mcg / kg for fentanyl analgesia and 0.5mg / kg propofol with a concentration of 5mg / ml is prescribed if more sedation is needed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is a plan to make this available